Substantial Reduction of Platelet Adhesion by Heparin-Coated Stents
| Autor: | Frank Krummenauer, Hans J. Rupprecht, Christiane Binz, Christoph Bickel, Harald Darius, Jürgen Meyer, Bärbel Hauröder |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
medicine.medical_specialty
Platelet adhesion medicine.medical_treatment In Vitro Techniques engineering.material Platelet Adhesiveness Restenosis Coating medicine Humans Radiology Nuclear Medicine and imaging Platelet Whole blood Heparin business.industry Graft Occlusion Vascular Anticoagulants Stent Adhesion equipment and supplies medicine.disease Surgery engineering Stents Cardiology and Cardiovascular Medicine business Biomedical engineering medicine.drug |
| Zdroj: | Journal of Interventional Cardiology. 14:407-413 |
| ISSN: | 1540-8183 0896-4327 |
| DOI: | 10.1111/j.1540-8183.2001.tb00350.x |
| Popis: | Although optimized antiplatelet medication has improved the clinical outcome after coronary stenting, vessel occlusion and restenosis still remain a relevant clinical problem. Platelets play a key role in this process. Therefore, the authors compared the platelet adhesion on different stent surface modifications (electropolished without coating or coated with carbon, carbon and additional heparin, silicon carbide, or heparin alone) to investigate their role in reducing platelet adhesion. All stents and additional stainless steel plates were incubated in heparinized whole blood with radiolabeled platelets. After washing the stents and plates four times, radioactivity caused by the adhesion of radiolabeled platelets was measured. The adhesion of radiolabeled platelets, compared to uncoated, electropolished stents, was reduced through silicon carbide coating to 58.6%, by carbon coating with additional heparin to 32.9%, and heparin coating alone to 7.7%. Stent coating with heparin is the most effective among the examined coatings in reducing platelet adhesion in vitro. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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