Prevalence and factors associated with anxiety and depressive symptoms among patients hospitalized with hematological malignancies after chimeric antigen receptor T-cell (CAR-T) therapy: A cross-sectional study
| Autor: | Tingyu Hu, Junnian Zheng, Shuya Xu, Jing Han, Xue Dou, Hongxia Li, Zhenyu Li, Hongyuan Dai, Jing Wei, Jiang Cao, Fang Zhou |
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| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Cross-sectional study T-Lymphocytes T cell Anxiety Lower risk Immunotherapy Adoptive 03 medical and health sciences 0302 clinical medicine Surveys and Questionnaires Internal medicine Prevalence medicine Humans Depressive symptoms Receptors Chimeric Antigen Depression business.industry Middle Aged Middle age Chimeric antigen receptor 030227 psychiatry Psychiatry and Mental health Clinical Psychology Cross-Sectional Studies medicine.anatomical_structure Spouse Hematologic Neoplasms medicine.symptom business 030217 neurology & neurosurgery |
| Zdroj: | Journal of Affective Disorders. 286:33-39 |
| ISSN: | 0165-0327 |
| Popis: | Background : We conducted a survey to investigate the prevalence and factors associated with anxiety and depressive symptoms among patients hospitalized with hematological malignancies after chimeric antigen receptor T-cell (CAR-T) therapy. Methods : In total, 130 eligible patients completed the Self-Rating Anxiety Scale and Self-Rating Depression Scale at week 4 after CAR-T cell infusion. We collected sociodemographic information during the same period. We studied factors associated with anxiety and depressive symptoms using logistic regression analysis. Results : The prevalence of anxiety and depressive symptoms at week 4 after infusion were 13.8% and 40.0%, respectively. A cutoff value of 50 or above indicates significantly anxiety and depressive symptoms. Binary logistic regression analysis showed that high school education and above (OR = 0.22, 95% CI = 0.06–0.78) and middle age (OR = 0.16, 95% CI = 0.03–0.90) were associated with lower risk of anxiety symptoms, and increased odds of depressive symptoms was associated with old age (OR = 11.39, 95% CI = 2.50–51.88), non-manual occupations before illness (OR = 3.72, 95% CI = 1.20–11.58), and higher healthcare expenditure (OR = 3.93, 95% CI = 1.50–10.33), while lower risk of depressive symptoms was associated with rural household location (OR = 0.25, 95% CI = 0.08–0.76) and being cared for by spouse (OR = 0.12, 95% CI = 0.02–0.63). Conclusions : Patients receiving CAR-T therapy with lower education background, old ages, urban household location, or who used to work as non-manual workers require more attention and psychological care. Support from a spouse and medical expense deductions from the government may help patients develop positive attitudes. |
| Databáze: | OpenAIRE |
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