Optimized Cytocompatibility and Antimicrobial Activity of Octacalcium Phosphate/ε-Polylysine Composite Coating Electrochemically Codeposited on Medical Titanium
| Autor: | Gang Rui, Changjian Lin, Jiejie Hu, Qiaoling Huang, Yanmei Zhang, Ren Hu, Yun Yang, Lili Fan |
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| Rok vydání: | 2022 |
| Předmět: |
E-polylysine
biology Chemistry Bone implant Biochemistry (medical) Biomedical Engineering chemistry.chemical_element Biological activity General Chemistry Antimicrobial biology.organism_classification Biomaterials chemistry.chemical_compound Composite coating Chemical engineering Octacalcium phosphate Bacteria Titanium |
| Zdroj: | ACS applied bio materials. 3(1) |
| ISSN: | 2576-6422 |
| Popis: | Preventing bacterial infection of bone implants is a major challenge for developing functional biomedical materials at present. With more significant emergence of drug-resistant bacteria, exploration of antimicrobial materials has become increasingly important and urgent. More and more researchers have devoted their work to the study of a kind of antimicrobial material for improving inhibition of drug-resistant bacteria, and other bioproperties as well. In this work, we first introduced ε-polylysine (ε-PL), which possessed a broad antibacterial spectrum and negligible cytotoxicity to the human body, into an octacalcium phosphate (OCP) coating on a titanium surface by electrochemical codeposition (ED). The measurements of the structure and composition of the OCP/ε-PL composite coating demonstrated that ε-PL had succeeded in combining with OCP. The bioactivity assessment of all samples indicated that the OCP/ε-PL composite film had owned good biological mineralization capability. In vitro, it also had better ability to promote cell proliferation and differentiation when the concentration of ε-PL was 10 mg/mL compared with other concentrations. In the meanwhile, the antibacterial test indicated that the ε-PL introduced to OCP was able to markedly improve the antibacterial property against both Gram-positive and Gram-negative bacteria. |
| Databáze: | OpenAIRE |
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