Assessment of Ki67 in Breast Cancer: Updated Recommendations from the International Ki67 in Breast Cancer Working Group

Autor: Torsten O Nielsen, Samuel C. Y Leung, David L Rimm, Andrew Dodson, Balazs Acs, Sunil Badve, Carsten Denkert, Matthew J Ellis, Susan Fineberg, Margaret Flowers, Hans H Kreipe, Anne-Vibeke Laenkholm, Hongchao Pan, Frédérique M Penault-Llorca, Mei-Yin Polley, Roberto Salgado, Ian E Smith, Tomoharu Sugie, John M. S Bartlett, Lisa M McShane, Mitch Dowsett, Daniel F Hayes
Přispěvatelé: Imagerie Moléculaire et Stratégies Théranostiques (IMoST), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020]), Centre Jean Perrin [Clermont-Ferrand] (UNICANCER/CJP), UNICANCER
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Zdroj: O Nielson, T, C. Y. Leung, S, L. Rimm, D, Dodson, A, Acs, B, Badve, S, Denkert, C, J. Ellis, M, Fineberg, S, Flowers, M, H. Kreipe, H, Laenkholm, A-V, Pan, H, M Penault-Llorca, F, Polley, M-Y, Salgado, R, E. Smith, I, Sugie, T, Bartlett, J, M McShane, L, Dowsett, M & F Hayes, D 2020, ' Assessment of Ki67 in Breast Cancer: Updated Recommendations from the International Ki67 in Breast Cancer Working Group ', JNCI: Journal of the National Cancer Institute .
Nielsen, T O, Leung, S C Y, Rimm, D L, Dodson, A, Acs, B, Badve, S, Denkert, C, Ellis, M J, Fineberg, S, Flowers, M, Kreipe, H H, Laenkholm, A-V, Pan, H, Penault-Llorca, F M, Polley, M-Y, Salgado, R, Smith, I E, Sugie, T, Bartlett, J M S, McShane, L M, Dowsett, M & Hayes, D F 2021, ' Assessment of Ki67 in Breast Cancer : Updated Recommendations from the International Ki67 in Breast Cancer Working Group ', JNCI-Journal of the National Cancer Institute, vol. 113, no. 7, pp. 808–819 . https://doi.org/10.1093/jnci/djaa201
JNCI: Journal of the National Cancer Institute
JNCI: Journal of the National Cancer Institute, Oxford University Press (OUP), 2020, ⟨10.1093/jnci/djaa201⟩
JNCI Journal of the National Cancer Institute
ISSN: 0027-8874
1460-2105
Popis: Ki67 immunohistochemistry (IHC), commonly used as a proliferation marker in breast cancer, has limited value for treatment decisions due to questionable analytical validity. The International Ki67 in Breast Cancer Working Group (IKWG) consensus meeting, held in October 2019, assessed the current evidence for Ki67 IHC analytical validity and clinical utility in breast cancer, including the series of scoring studies the IKWG conducted on centrally stained tissues. Consensus observations and recommendations are: 1) as for estrogen receptor and HER2 testing, preanalytical handling considerations are critical; 2) a standardized visual scoring method has been established and is recommended for adoption; 3) participation in and evaluation of quality assurance and quality control programs is recommended to maintain analytical validity; and 4) the IKWG accepted that Ki67 IHC as a prognostic marker in breast cancer has clinical validity but concluded that clinical utility is evident only for prognosis estimation in anatomically favorable estrogen receptor–positive and HER2-negative patients to identify those who do not need adjuvant chemotherapy. In this T1-2, N0-1 patient group, the IKWG consensus is that Ki67 5% or less, or 30% or more, can be used to estimate prognosis. In conclusion, analytical validity of Ki67 IHC can be reached with careful attention to preanalytical issues and calibrated standardized visual scoring. Currently, clinical utility of Ki67 IHC in breast cancer care remains limited to prognosis assessment in stage I or II breast cancer. Further development of automated scoring might help to overcome some current limitations.
Databáze: OpenAIRE
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