The anticancer activity of chalcone compounds against human prostate carcinoma cell and human colon colorectal adenocarcinoma

Autor:	Ayşe Şahin Yağlioğlu, Bedriye Seda Kurşun Aktar, Emine Elçin Oruç-Emre
Rok vydání:	2021
Předmět:	Chalcone business.industry General Medicine HT29 PC3 Chalcone 5-Fluorouracil Fluor atom anticancer activity Human prostate chemistry.chemical_compound chemistry Carcinoma Cell Cancer research Medicine Colorectal adenocarcinoma business Biology Biyoloji Human colon
Zdroj:	Volume: 5, Issue: 1 52-58 International Journal of Chemistry and Technology
ISSN:	2602-277X
DOI:	10.32571/ijct.910580
Popis:	The anticancer activities 3-(substituted phenyl)-1-[4-(morpholine-4-yl)phenyl]prop-2-en-1-one derivatives were investigated against PC3 (Human Prostate Carcinoma Cell) and HT29 (Human colon colorectal adenocarcinoma) cell lines. The anticancer activity tests were performed by the BrdU ELISA method. 5-Fluorouracil (5-FU) was used as standard compound. Compound 1-7 (except Compound 3) were determined to have higher anticancer activity than 5-FU aganist PC3 cancer cells. IC50 values of the Compounds 1-7 against PC3 cancer cells were 2.53±0.02 µM; 4.40±0.03 µM; 4.36±0.03 µM; 1.76±0.02 µM; 1.78±0.03 µM; 2.31±0.03 µM, respectively.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::227ee86a5c2fc0f22e6c83ae132eefc6 https://doi.org/10.32571/ijct.910580 Zobrazit plný text záznamu