Injectable peramivir mitigates disease and promotes survival in ferrets and mice infected with the highly virulent influenza virus, A/Vietnam/1203/04 (H5N1)
| Autor: | Natallia Dziuba, Ian G. Barr, Slobodan Paessler, Lifang Zhang, Michele A. Zacks, Nathaniel S. Linde, Jeanon N. Smith, C. Shane Arnold, Nadezhda E. Yun, J. M. Kilpatrick, Aeron C. Hurt, Michael R. Holbrook |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Oseltamivir
Acids Carbocyclic Avian influenza Cyclopentanes Biology medicine.disease_cause Antiviral Agents Guanidines Injections Intramuscular Article Virus Mice 03 medical and health sciences chemistry.chemical_compound Orthomyxoviridae Infections Virology medicine Influenza A virus Pathogenicity Animals Animal model Lung Survival analysis 030304 developmental biology 0303 health sciences Virulence Influenza A Virus H5N1 Subtype 030306 microbiology Ferrets virus diseases Survival Analysis Influenza A virus subtype H5N1 3. Good health Titer Treatment Outcome chemistry Peramivir Nasal administration medicine.drug |
| Zdroj: | Virology. 374(1):198-209 |
| ISSN: | 0042-6822 |
| DOI: | 10.1016/j.virol.2007.12.029 |
| Popis: | The post-exposure therapeutic efficacy of injectable peramivir against highly pathogenic avian influenza type A H5N1 was evaluated in mice and in ferrets. Seventy to eighty percent of the H5N1-infected peramivir-treated mice, and 70% in the oseltamivir treated mice survived the 15-day study period, as compared to 36% in control (vehicle) group. Ferrets were infected intranasally with H5N1 followed by treatment with multiple doses of peramivir. In two of three trials, a statistically significant increase in survival over a 16–18 day period resulted from peramivir treatment, with improved survival of 40–64% in comparison to mock-treated or untreated animals. Injected peramivir mitigates virus-induced disease, reduces infectious virus titers in the lungs and brains and promotes survival in ferrets infected intranasally with this highly neurovirulent isolate. A single intramuscular peramivir injection protected mice against severe disease outcomes following infection with highly pathogenic avian influenza and multi-dose treatment was efficacious in ferrets. |
| Databáze: | OpenAIRE |
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