Quantifying the impact of tissue metabolism on solute transport in feto-placental microvascular networks
| Autor: | Alexander Erlich, Igor L. Chernyavsky, Paul Brownbill, Gareth A. Nye, Oliver E. Jensen |
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| Rok vydání: | 2019 |
| Předmět: |
Capillary action
Kinetics Biomedical Engineering Biophysics FOS: Physical sciences microcirculation Bioengineering Biochemistry Microcirculation Biomaterials 03 medical and health sciences 0302 clinical medicine human placenta Tissue metabolism Physics - Biological Physics Tissues and Organs (q-bio.TO) 030304 developmental biology 0303 health sciences Fetus Chemistry Human placenta Quantitative Biology - Tissues and Organs Articles Flow conditions Fetal circulation Biological Physics (physics.bio-ph) FOS: Biological sciences solute transport embryonic structures metabolism 030217 neurology & neurosurgery Biotechnology Research Article |
| Zdroj: | Interface Focus Erlich, A, Nye, G A, Brownbill, P, Jensen, O E & Chernyavsky, I L 2019, ' Quantifying the impact of tissue metabolism on solute transport in feto-placental microvascular networks ', Interface Focus . https://doi.org/10.1098/rsfs.2019.0021 |
| ISSN: | 2042-8898 |
| DOI: | 10.1098/rsfs.2019.0021 |
| Popis: | The primary exchange units in the human placenta are terminal villi, in which fetal capillary networks are surrounded by a thin layer of villous tissue, separating fetal from maternal blood. To understand how the complex spatial structure of villi influences their function, we use an image-based theoretical model to study the effect of tissue metabolism on the transport of solutes from maternal blood into the fetal circulation. For solute that is taken up under first-order kinetics, we show that the transition between flow-limited and diffusion-limited transport depends on two new dimensionless parameters defined in terms of key geometric quantities, with strong solute uptake promoting flow-limited transport conditions. We present a simple algebraic approximation for solute uptake rate as a function of flow conditions, metabolic rate and villous geometry. For oxygen, accounting for nonlinear kinetics using physiological parameter values, our model predicts that villous metabolism does not significantly impact oxygen transfer to fetal blood, although the partitioning of fluxes between the villous tissue and the capillary network depends strongly on the flow regime. |
| Databáze: | OpenAIRE |
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