New metabolites from the sponge-derived fungus Aspergillus sydowii J05B-7F-4
| Autor: | Jongki Hong, Mingzhi Su, Gwi Ja Hwang, Haibo Wang, Sen Liu, Jee H. Jung |
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| Rok vydání: | 2017 |
| Předmět: |
Staphylococcus aureus
Plant Science Nitric Oxide 01 natural sciences Biochemistry Analytical Chemistry Microbiology chemistry.chemical_compound Stelletta Cell Line Tumor Xanthone Animals Humans Aspergillus sydowii Streptococcus iniae Cytotoxicity chemistry.chemical_classification Molecular Structure biology 010405 organic chemistry Organic Chemistry Glycoside biology.organism_classification Anti-Bacterial Agents Porifera 0104 chemical sciences 010404 medicinal & biomolecular chemistry Aspergillus chemistry Chromone Antibacterial activity Sesquiterpenes |
| Zdroj: | Natural Product Research. 31:1682-1686 |
| ISSN: | 1478-6427 1478-6419 |
| Popis: | Two new metabolites, diorcinolic acid (1) and β-d-glucopyranosyl aspergillusene A (8), together with six diphenylethers (2–7), a diketopiperazine (9), a chromone (10) and a xanthone (11) were isolated from the fungus Aspergillus sydowii derived from the marine sponge Stelletta sp. The planar structures and their relative configurations were elucidated by analysing 1D, 2D NMR and HRESIMS data. Compound 8 is the first glycoside of phenolic bisabolane sesquiterpenes. Compounds 1 and 8 exhibited mild cytotoxicity against KB (human nasopharyngeal carcinoma cells), HepG2 (human liver cancer cells) and HCT 116 (human colon cancer cells). All compounds were evaluated for antibacterial activity and their abilities to suppress LPS-induced nitric oxide (NO) production. Compounds 2 and 4–7 showed mild antibacterial activity against human pathogen Staphylococcus aureus and fish pathogens Streptococcus iniae and Vibrio ichthyoenteri, and compounds 4 and 7 weakly suppressed NO production. |
| Databáze: | OpenAIRE |
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