3-Year Follow-Up of Radiation-Associated Changes in Diastolic Function by Speckle Tracking Echocardiography
| Autor: | Pirkko-Liisa Kellokumpu-Lehtinen, Heini Huhtala, Vesa Virtanen, Suvi Sirkku Tuohinen, Tuija Poutanen, Tanja Skyttä, Pekka Raatikainen |
|---|---|
| Přispěvatelé: | HUS Heart and Lung Center, Department of Medicine, Kardiologian yksikkö, Helsinki University Hospital Area, University of Helsinki, Tampere University, TAYS Heart Centre, Clinical Medicine, Department of Oncology, Health Sciences, Department of Paediatrics |
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_treatment
RT radiotherapy Speckle tracking echocardiography 030204 cardiovascular system & hematology SR strain rate TOXICITY DISEASE LVEF - Left ventricular ejection fraction GLOBAL STRAIN-RATE 0302 clinical medicine SRs systolic strain rate LVEF left ventricular ejection fraction Diastolic function skin and connective tissue diseases Original Research diastolic strain rate DAMAGE RISK SRedep global early diastolic strain rate <1 s-1 LAVI left atrial volume indexed to body surface area 3. Good health Oncology Diffuse fibrosis 030220 oncology & carcinogenesis Cardiology BREAST-CANCER PATIENTS Cardiology and Cardiovascular Medicine DLVmax maximal left ventricular radiation dose medicine.medical_specialty 3122 Cancers SRe early diastolic strain rate 3121 Internal medicine MECHANISMS 03 medical and health sciences breast cancer Breast cancer Internal medicine SReapex apical early diastolic strain rate medicine speckle tracking echocardiography LV left ventricular IQR interquartile range radiotherapy ΔGLS15 relative decline of more than 15% in global longitudinal strain business.industry medicine.disease DYSFUNCTION 3141 Health care science CI confidence interval Radiation therapy RT - Radiotherapy 3121 General medicine internal medicine and other clinical medicine GLS global longitudinal strain Radiation associated sense organs business |
| Zdroj: | JACC: CardioOncology |
| ISSN: | 2666-0873 |
| Popis: | Background Radiation therapy (RT) results in myocardial changes consisting of diffuse fibrosis, which may result in changes in diastolic function. Objectives The aim of this study was to explore RT-associated changes in left ventricular (LV) diastolic function. Methods Sixty chemotherapy-naive patients with left-sided, early-stage breast cancer were studied with speckle tracking echocardiography at 3 time points: prior to, immediately after, and 3 years after RT. Global and regional early diastolic strain rate (SRe) were quantified, as were parameters of systolic function. Results Regional changes in SRe, particularly the apical and anteroseptal segments, were observed over time and were more evident than global changes. The apical SRe declined from a median of 1.24 (interquartile range: 1.01 to 1.39) s-1 at baseline to 1.02 (interquartile range: 0.79 to 1.15) s-1 at 3 years of follow-up (p < 0.001). This decline was associated with the left ventricular maximal radiation dose (β = 0.36, p = 0.007). The global SRe was Central Illustration |
| Databáze: | OpenAIRE |
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