Peculiarities in cases of spina bifida cystica managed recently in south-east Nigeria: could antimalarial drugs be a major but unrecognized etiologic factor?
| Autor: | J K C Emejulu, Blaise Ogedi Okwaraoha |
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| Rok vydání: | 2010 |
| Předmět: |
Male
congenital hereditary and neonatal diseases and abnormalities Pediatrics medicine.medical_specialty Nigeria Disease Folic Acid Deficiency Antimalarials Caudal neuropore Pregnancy Risk Factors South east medicine Humans Prospective Studies Spinal Dysraphism business.industry Spina bifida Infant Newborn Infant General Medicine medicine.disease nervous system diseases First trimester Pregnancy Trimester First Spina Bifida Cystica Child Preschool Prenatal Exposure Delayed Effects Pediatrics Perinatology and Child Health Surgery Female Neurology (clinical) business |
| Zdroj: | Pediatric neurosurgery. 47(3) |
| ISSN: | 1423-0305 |
| Popis: | Background: Spina bifida is a long-known disease arising from the incomplete fusion of the caudal neuropore in the first month of intrauterine life. It is thought to have a multifactorial etiology, the most important of which is folic acid deficiency. In evaluating its etiology, the role of antifolate agents like antimalarial drugs is rarely given a strong mention. Methods/Patients: This is a 44-month prospective study of consecutive cases of spina bifida cystica presenting to the Neurosurgery Unit of Nnamdi Azikiwe University Teaching Hospital, Nnewi, South-East Nigeria. Data collection was with a structured proforma from presentation, and collation done with Microsoft Excel broadsheet and data analysis with SPSS and χ2 test. Results: A total of 41 cases of spina bifida were attended to within the period, with 92.7% cases of spina bifida cystica. Most presented by >12–24 months, with a consistent history of maternal ingestion of antimalarial drugs during the first trimester of pregnancy. Conclusion: Spina bifida cystica was diagnosed mostly in children whose mothers ingested antimalarial drugs during the first trimester of gestation. There may be a need to critically evaluate the contribution of antimalarial drugs to the etiopathogenesis of this malformation and develop safer antimalarial treatment in pregnancy. |
| Databáze: | OpenAIRE |
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