Ischemic nephropathy: proteinuria and renal resistance index could suggest if revascularization is recommended

Autor:	Domenico Di Donato, Raffaella Lavini, Lelio Polidori, Paola Martina, Antonietta Gigante, Roberta Renzulli, Gilda Stivali, Biagio Barbano, Rosario Cianci, Matteo Cianci, Silvia Lai
Rok vydání:	2010
Předmět:	Male renal failure medicine.medical_specialty Percutaneous medicine.medical_treatment Urology Renal function Renal Artery Obstruction urologic and male genital diseases Critical Care and Intensive Care Medicine Renal artery stenosis Revascularization chemistry.chemical_compound Internal medicine medicine Humans percutaneous transluminal angioplasty and stenting Aged Creatinine Proteinuria proteinuria renal resistance index business.industry Angioplasty General Medicine Middle Aged Atherosclerosis medicine.disease chemistry Nephrology Hemorheology Disease Progression Cardiology Ischemic Nephropathy Female Stents medicine.symptom business Blood Flow Velocity Kidney disease
Zdroj:	Renal Failure. 32:1167-1171
ISSN:	1525-6049 0886-022X
DOI:	10.3109/0886022x.2010.516856
Popis:	The aim of endovascular therapy in renal artery stenosis (RAS) is to preserve renal function and have a better hypertension control. The purpose of our study was to determine which biochemical and instrumental parameters could predict a better renal outcome in patients with RAS treated with percutaneous transluminal angioplasty and stenting (RPTAS).We performed an observational study based on 40 patients with RAS who met the following criteria before revascularization: urinary protein excretion of over 250 mg/24 h, normal renal function, and/or mild-moderate renal insufficiency (I, II, and III levels of classification of chronic kidney disease, K-DOQI).Assessment at 12 months after RPTAS showed in 20 patients (Group A) that proteinuria serum creatinine (Scr) and creatinine clearance (CrCl) significantly worsened from the baseline; whereas in 20 patients (Group B) proteinuria remained unchanged and the renal function improved after the procedure.In our study, the decline of renal function after RPTAS is associated with an elevated renal resistance index (RI) in both kidneys (0.83 ± 0.2) and preexisting proteinuria.
Databáze:	OpenAIRE
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