Prostacyclin effect on cardiovascular system in man evaluated by echocardiography
| Autor: | G.C. Maggi, G. Balice, G. Aguggini, F. Gentile, Triulzi Mo, Cirino D |
|---|---|
| Rok vydání: | 1981 |
| Předmět: |
Adult
Male medicine.medical_specialty Diastole Cardiac index Blood Pressure Cardiovascular System Afterload Heart Rate Internal medicine Heart rate Humans Medicine Ejection fraction business.industry Stroke Volume General Medicine Stroke volume Epoprostenol Myocardial Contraction Vasodilation medicine.anatomical_structure Echocardiography Ventricle Anesthesia Prostaglandins Vascular resistance Cardiology Female Vascular Resistance business |
| Zdroj: | Prostaglandins and Medicine. 7:501-510 |
| ISSN: | 0161-4630 |
| Popis: | This was an echocardiographic study of the cardiovascular effects of rostacclin (PGI 2 ) infused intravenously to human volunteers at the rate of 20 ng⊎ Kg − ⊎ min − for 10 Anutes. The following parameters were recorded in the steady state , at one-minute intervals throughout infusion and the ensuing recovery period: systolic, diastolic, and mean blood pressure ( SBP, DBP, MBP); heart rate (HR); left ventricle end-diastolic (EDD) and end-systolic diameter (ESD); stroke volume index ( SVI); cardiac index (CI); peripheral vascular resistance (PVR); left ventricle fractional shortening (FS) and ejection fraction (EF). We detected a progressive reduction of MBP without any HR modification. MBP reduction was associated with a reduction of PVR and a parallel rise of CI and SVI. There was also an increase of FS and EF reflecting a reduced ESD. We conclude that PGI 2 infused in man at the rate stated above causes hypotension reflecting an arterial vasodilating effect; a lack of heart rate reflex response to afterload reduction (probably a nerve-mediated effect of PGI ); and no venous vasodilation, judging from the absence of any change in end-diastolic diameter. |
| Databáze: | OpenAIRE |
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