Endocrinological Basis of Sex Differences in Cocaine-Induced Behavioral Responses
| Autor: | Shirzad Jenab, Sosimo J. Fabian, Linda I. Perrotti, Juliet Chin, Vanya Quinones-Jenab, Scott J. Russo |
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| Rok vydání: | 2006 |
| Předmět: |
Central Nervous System
Male medicine.medical_specialty medicine.drug_class Central nervous system Endocrine System Affect (psychology) General Biochemistry Genetics and Molecular Biology Sex Factors Cocaine Dopamine Uptake Inhibitors Estrus History and Philosophy of Science Internal medicine medicine Animals Endocrine system Testosterone Gonads Progesterone General Neuroscience Rats Endocrinology medicine.anatomical_structure Estrogen Receptors Opioid Female Psychology Neuroscience Cocaine abuse |
| Zdroj: | Annals of the New York Academy of Sciences. 937:140-171 |
| ISSN: | 1749-6632 0077-8923 |
| Popis: | Currently, 1.8 million Americans use cocaine, 30% of whom are females. Sex differences in the pattern of cocaine abuse may reside in neuroendocrinological modulations that affect the use of and/or dependence on cocaine. This review discusses sex differences in cocaine-induced behavioral and molecular alterations in the central nervous system, with emphasis on the role of endocrine responses in the neuronal modulations of this drug. Mechanisms and data supporting the role of the hypothalamic-gonadal axis in the modulation of cocaine-induced behavioral and molecular alterations are also provided. |
| Databáze: | OpenAIRE |
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