Vascular endothelial growth factor receptor-3 expression in mycosis fungoides
| Autor: | Qian Zhang, Thorbjørn Krejsgaard, Carsten Geisler, Anders Woetmann, Mariusz A. Wasik, Ida Holst Pedersen, Andreas Willerslev-Olsen, Jürgen C. Becker, Charlotte M. Bonefeld, Britt Lauenborg, Claudia S. Vetter-Kauczok, Katharina L. Kopp, Sally Dabelsteen, Niels Ødum |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Cancer Research
Pathology medicine.medical_specialty Stromal cell Skin Neoplasms medicine.drug_class Angiogenesis Transplantation Heterologous Vascular Endothelial Growth Factor C Gene Expression Biology chemistry.chemical_compound Mice Mycosis Fungoides Cell Line Tumor medicine Animals Humans RNA Messenger Mycosis fungoides Histone deacetylase inhibitor Hematology medicine.disease Vascular Endothelial Growth Factor Receptor-3 Lymphangiogenesis Vascular endothelial growth factor Disease Models Animal Oncology chemistry Cancer research Immunohistochemistry Growth inhibition |
| Zdroj: | Leukemialymphoma. 54(4) |
| ISSN: | 1029-2403 |
| Popis: | Here, we have studied vascular endothelial growth factor receptor-3 (VEGFR-3) expression in mycosis fungoides (MF), the most common type of cutaneous T-cell lymphoma (CTCL). Immunohistochemistry revealed that in two-thirds of 34 patients, VEGFR-3 was expressed in situ by both tumor and stromal cells irrespective of the disease stage. The natural VEGFR-3 ligand, VEGF-C, partially protected malignant T-cell lines from growth inhibition by the histone deacetylase inhibitor, suberoylanilide hydroxamic acid (SAHA). Whereas the malignant T cells did not produce VEGF-C in vitro, its expression was induced during tumor formation in vivo in a xenograft mouse model of MF. In conclusion, malignant and stromal cells express high levels of VEGFR-3 in all stages of MF. Moreover, malignant T cells trigger enhanced VEGF-C expression in fibroblasts, suggesting that cross-talk between tumor and stromal cells plays a role in lymphangiogenesis and possibly disease progression. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|