Vancomycin Analogues Containing Monosaccharides Exhibit Improved Antibiotic Activity: A Combined One-Pot Enzymatic Glycosylation and Chemical Diversification Strategy

Autor: Chi-Huey Wong, Desiree A. Thayer
Rok vydání: 2006
Předmět:
Zdroj: Chemistry – An Asian Journal. 1:445-452
ISSN: 1861-471X
1861-4728
DOI: 10.1002/asia.200600084
Popis: Many natural products contain carbohydrate moieties that contribute to their biological activity. Manipulation of the carbohydrate domain of natural products through multiple glycosylations to identify new derivatives with novel biological activities has been a difficult and impractical process. We report a practical one-pot enzymatic approach with regeneration of cosubstrates to synthesize analogues of vancomycin that contain an N-alkyl glucosamine, which exhibited marked improvement in antibiotic activity against a vancomycin-resistant strain of Enterococcus.
Databáze: OpenAIRE