Vancomycin Analogues Containing Monosaccharides Exhibit Improved Antibiotic Activity: A Combined One-Pot Enzymatic Glycosylation and Chemical Diversification Strategy
Autor: | Chi-Huey Wong, Desiree A. Thayer |
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Rok vydání: | 2006 |
Předmět: |
Glycosylation
Chemistry Pharmaceutical Carbohydrates Microbial Sensitivity Tests Biochemistry Catalysis chemistry.chemical_compound Polysaccharides Vancomycin Glucosamine Technology Pharmaceutical Monosaccharide chemistry.chemical_classification biology Monosaccharides Organic Chemistry Biological activity General Chemistry Carbohydrate biology.organism_classification Glycopeptide Anti-Bacterial Agents Enzyme Models Chemical chemistry Enterococcus Drug Design Peptides |
Zdroj: | Chemistry – An Asian Journal. 1:445-452 |
ISSN: | 1861-471X 1861-4728 |
DOI: | 10.1002/asia.200600084 |
Popis: | Many natural products contain carbohydrate moieties that contribute to their biological activity. Manipulation of the carbohydrate domain of natural products through multiple glycosylations to identify new derivatives with novel biological activities has been a difficult and impractical process. We report a practical one-pot enzymatic approach with regeneration of cosubstrates to synthesize analogues of vancomycin that contain an N-alkyl glucosamine, which exhibited marked improvement in antibiotic activity against a vancomycin-resistant strain of Enterococcus. |
Databáze: | OpenAIRE |
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