A glucocorticoid receptor agonist improves post-weaning growth performance in segregated early-weaned pigs
| Autor: | Anoosh Rakhshandeh, Mitchell S. Wachtel, Hailey Wooten, Amanda R Rakhshandeh, John J. McGlone, G. Thompson |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Agonist
productivity 040301 veterinary sciences medicine.drug_class Swine medicine.medical_treatment dexamethasone Weaning SF1-1100 Antioxidants 0403 veterinary science Jejunum stress Animal science Receptors Glucocorticoid Stress Physiological Blood plasma medicine Animals Saline Glucocorticoids Dexamethasone Meal immunocompetence biology Haptoglobin Body Weight 0402 animal and dairy science 04 agricultural and veterinary sciences 040201 dairy & animal science Animal Feed Diet Animal culture Intestines medicine.anatomical_structure inflammation biology.protein Animal Science and Zoology Female Soybeans medicine.drug |
| Zdroj: | Animal, Vol 13, Iss 9, Pp 1972-1981 (2019) |
| ISSN: | 1751-7311 |
| Popis: | While beneficial for sow reproductive efficiency and biosecurity, segregated early weaning (SEW) leads to a systemic immune response that adversely affects the digestive physiology and post-weaning growth of pigs. Two experiments were conducted to evaluate the effects of a glucocorticoid receptor agonist (GA) on growth performance, measures of immune function and intestinal integrity of SEW pigs. In both experiments, pigs were fed corn-soybean meal-based starter diets. In the first experiment, 48 pigs (initial BW 4.8 ± 0.7 kg) were weaned at 21 ± 1 days and randomly assigned to three GA treatment groups: 0, 0.2 and 0.6 mg GA/kg of BW injected intramuscularly. Treatments were administered one day before weaning. Pigs in the 0 mg GA group received sterile saline in place of GA. Body weight was measured daily from one day before to 7 days post-weaning, and then weekly until 28 days post-weaning. Piglets treated with 0.2 mg GA had a higher BW than piglets in other treatment groups during the 28-day course of the study (P |
| Databáze: | OpenAIRE |
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