Inhibition of human immunodeficiency virus (HIV) type 1 multiplication by an avian cellular factor
| Autor: | Claude Jasmin, D. Coulaud, A. Alileche, José J. Aguilar, M. Semmel, P. Krief |
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| Rok vydání: | 1992 |
| Předmět: |
Transcription
Genetic CD8 Antigens T-Lymphocytes viruses Blotting Western Mutant Chick Embryo Lymphocyte Activation Virus Replication Vesicular stomatitis Indiana virus Virus Cell Line Virology medicine Animals RNA Messenger Stomatitis Messenger RNA biology General Medicine Fibroblasts Rhabdoviridae Blotting Northern medicine.disease biology.organism_classification Microscopy Electron Infectious disease (medical specialty) Vesicular stomatitis virus CD4 Antigens HIV-1 Cytokines RNA Viral Vesiculovirus |
| Zdroj: | Archives of Virology. 123:309-321 |
| ISSN: | 1432-8798 0304-8608 |
| DOI: | 10.1007/bf01317266 |
| Popis: | A factor secreted from avian cells infected non productively with a non cytopathogenic mutant of vesicular stomatitis virus (VSV ts 1026) interferes with HIV replication in CEM cells and peripheral blood monocytes (PBL). Production of infectious particles is decreased and many virions lack cores and/or spikes. In CEM cells the prmRNA is spliced into 7.5, 4, and 2 kb mRNA. Residual virus contains less env encoded proteins and p 18; p 25 appears as several bands. The processing of tat, rev. and nef proteins differs in treated cells and in controls. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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