Impairment of exploratory behavior and spatial memory in adolescent rats in lithium-pilocarpine model of temporal lobe epilepsy
| Autor: | N. Ya. Lukomskaya, K. Kh. Kim, E. V. Frolova, Lev G. Magazanik, V. V. Sizov, Aleksey V. Zaitsev, Olga E. Zubareva, S. V. Kalemenev, Valeria V. Lavrentyeva |
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| Rok vydání: | 2015 |
| Předmět: |
Male
medicine.medical_specialty Adolescent Morris water navigation task Status epilepticus Audiology General Biochemistry Genetics and Molecular Biology Open field Temporal lobe Epilepsy medicine Animals Humans Rats Wistar Maze Learning Spatial Memory Memory Disorders General Immunology and Microbiology business.industry Mental Disorders Pilocarpine Cognition General Medicine medicine.disease Rats Disease Models Animal Epilepsy Temporal Lobe Extinction (neurology) Exploratory Behavior Lithium Compounds medicine.symptom General Agricultural and Biological Sciences business medicine.drug |
| Zdroj: | Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections. 463 |
| ISSN: | 1608-3105 |
| Popis: | Cognitive impairment in six-week -old rats has been studied in the lithium-pilocarpine model of adolescent temporal lobe epilepsy in humans. The pilocarpine-treated rats (n =21) exhibited (a) a decreased exploratory activity in comparison with control rats (n = 20) in the open field (OP) test and (b) a slower extinction of exploratory behavior in repeated OP tests. The Morris Water Maze (MWM) test showed that the effect of training was less pronounced in the pilocarpine-treated rats, which demonstrated disruption of predominantly short-term memory. Therefore, our study has shown that lithium-pilocarpine seizures induce substantial changes in exploratory behavior and spatial memory in adolescent rats. OP and MWM tests can be used in the search of drugs reducing cognitive impairments associated with temporal lobe epilepsy. |
| Databáze: | OpenAIRE |
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