Association between FABP2 Ala54Thr polymorphisms and type 2 diabetes mellitus risk: a HuGE Review and Meta-Analysis
| Autor: | Chun-Jian Qiu, Xiao-Ren Peng, Xiao-Zheng Ye, Tong-Huan Li, Xiao-Juan Yu |
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| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
medicine.medical_specialty
Asia Genotype Mutation Missense Single-nucleotide polymorphism Biology Fatty Acid-Binding Proteins Polymorphism Single Nucleotide susceptibility Asian People Gene Frequency single nucleotide polymorphism Risk Factors Internal medicine medicine Odds Ratio Humans Genetic Predisposition to Disease Allele frequency fatty acid-binding protein 2 Genetics Case-control study Type 2 Diabetes Mellitus Cell Biology Odds ratio Original Articles Confidence interval meta-analysis Diabetes Mellitus Type 2 Meta-analysis Case-Control Studies Molecular Medicine Gene polymorphism |
| Zdroj: | Journal of Cellular and Molecular Medicine |
| ISSN: | 1582-4934 1582-1838 |
| Popis: | Many studies have examined the association between the FABP2 (rs1799883) Ala54Thr gene polymorphism and type 2 diabetes mellitus risk (T2DM) in various populations, but their results have been inconsistent. To assess this relationship more precisely, A HuGE review and meta-analysis were performed. The PubMed and CNKI database was searched for case-control studies published up to April 2014. Data were extracted and pooled odds ratios (OR) with 95% confidence intervals (CI) were calculated. Ultimately, 13 studies, comprising 2020 T2DM cases and 2910 controls were included. Overall, for the Thr carriers (Ala/Thr and Thr/Thr) versus the wild-type homozygotes (Ala/Ala), the pooled OR was 1.18 (95% CI = 1.04–1.34, P = 0.062 for heterogeneity), for Thr/Thr versus Ala/Ala the pooled OR was 1.17 (95% CI = 1.05–1.41 P = 0.087 for heterogeneity). In the stratified analysis by ethnicity, the significantly risks were found among Asians but not Caucasians. This meta-analysis suggests that the FABP2 (rs1799883) Ala54Thr polymorphisms are associated with increased susceptibility to T2DM risk among Asians but not Caucasians. |
| Databáze: | OpenAIRE |
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