Autoantibodies against oxidized low density lipoproteins in patients with stable angina, unstable angina or peripheral vascular disease - Pathophysiological implications
| Autor: | Giampaolo Niccoli, Filippo Crea, Claudia Monaco, Domenico Cianflone, Attilio Maseri, Giorgio Bellomo, Francesco Summaria, R. Bordone |
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| Přispěvatelé: | Monaco, C, Crea, F, Niccoli, G, Summaria, F, Cianflone, Domenico, Bordone, R, Bellomo, G, Maseri, A. |
| Rok vydání: | 2001 |
| Předmět: |
Male
medicine.medical_specialty Arteriosclerosis Inflammation Angina Pectoris Coronary artery disease Pathogenesis Internal medicine Humans Medicine Angina Unstable cardiovascular diseases Aged Autoantibodies Peripheral Vascular Diseases business.industry Vascular disease Unstable angina Autoantibody Middle Aged medicine.disease Pathophysiology Peripheral Lipoproteins LDL C-Reactive Protein Cardiology lipids (amino acids peptides and proteins) medicine.symptom Cardiology and Cardiovascular Medicine business |
| Popis: | Background Antibody antioxidized low density lipoproteins (oxLDL) might play a role both in atherogenesis and in the pathogenesis of acute coronary syndromes. Methods and Results Antibody titres to oxLDL and levels of C-reactive protein were compared in unstable angina, stable angina or peripheral artery disease. Antibody titres to LDL oxidated by CuSO4 for 2. 4 and 18 h (Cu-oxLDL-Ab(2-4-18)) or by peroxidase (HRP-oxLDL-Ab) were assessed by ELISA. Cu-oxLDL-Ab(2-4-18) were consistently higher in peripheral artery disease than in unstable angina (P < 0.001. P < 0.001, P = 0.01. respectively) or in stable angina (P < 0.001. P = 0.01. P = ns) but similar in unstable and stable angina. Accordingly, HRP-oxLDL-Ab were higher in peripheral artery disease than in unstable angina (P < 0.001) or stable angina (P = 0.04) but similar in unstable and stable angina. The number or arterial stenoses was higher in peripheral artery disease than unstable and stable angina (P < 0.01). Cu-oxLDL-Ab and HRP-oxLDL-Ab correlated with the severity of atherosclerosis (P < 0.01, R = 0.4: P = 0.02, R = 0.3 respectively). Conversely, C-reactive protein levels were higher in unstable than in stable angina (P < 0.001) or in peripheral artery disease (P < 0.03) but similar in stable angina and peripheral artery disease and did not correlate with the severity of atherosclerosis. Conclusion The autoimmune response to oxLDL is likely to play an important role in atherogenesis but not in precipitating acute coronary syndromes. (Eur Heart J 2001; 22: 1572-1577, doi:10.1053/euhj.2000. 2554) (C) 2001 The European Society of Cardiology. |
| Databáze: | OpenAIRE |
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