Cerebral White Matter Integrity in Amnestic Mild Cognitive Impairment: A 1-Year Randomized Controlled Trial of Aerobic Exercise Training
| Autor: | Kyle B. Womack, Rong Zhang, Linda S. Hynan, Ciwen Wang, Benjamin Y. Tseng, Takashi Tarumi, Binu P. Thomas, C. Munro Cullum, Hanzhang Lu |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Male
0301 basic medicine medicine.medical_specialty Anaerobic Threshold Prefrontal Cortex Neuropsychological Tests Corpus callosum 03 medical and health sciences 0302 clinical medicine Internal medicine Humans Medicine Dementia Aerobic exercise Cognitive Dysfunction Prefrontal cortex Exercise Aged business.industry General Neuroscience Neuropsychology VO2 max Cardiorespiratory fitness General Medicine Middle Aged medicine.disease Magnetic Resonance Imaging White Matter Exercise Therapy Psychiatry and Mental health Clinical Psychology Diffusion Tensor Imaging Treatment Outcome 030104 developmental biology Cardiorespiratory Fitness Cardiology Female Geriatrics and Gerontology business Psychomotor Performance 030217 neurology & neurosurgery Diffusion MRI |
| Zdroj: | Journal of Alzheimer's Disease. 73:489-501 |
| ISSN: | 1875-8908 1387-2877 |
| DOI: | 10.3233/jad-190875 |
| Popis: | Cerebral white matter (WM) represents the structural substrate of neuronal communications which is damaged by Alzheimer's disease (AD). Aerobic exercise training (AET) may improve WM integrity in cognitively normal older adults, but its efficacy remains unknown in patients with amnestic mild cognitive impairment (MCI), a prodromal phase of AD dementia. Therefore, we conducted a proof-of-concept study that randomized 70 amnestic MCI patients to a 1-year program of AET or a non-aerobic stretching and toning (SAT), active control group. Thirty-six patients completed both baseline and follow-up MRI scans, and cerebral WM integrity was measured by WM lesion volume and diffusion characteristics using fluid-attenuated-inversion-recovery and diffusion tensor imaging respectively. Peak oxygen uptake (VO2peak) and neuropsychological function were also measured. At baseline and 1-year follow-up, WM lesion volume and diffusion characteristics were similar between the AET and SAT groups, although VO2peak significantly improved after AET. The AET group showed slight improvement in neuropsychological performance. When analyzing individual data, tract-based spatial statistics demonstrated that VO2peak improvements are associated with attenuated elevations in mean and axial diffusivities, particularly the anterior WM fiber tracts (e.g., genu of corpus callosum). In patients with amnestic MCI, we found that although AET intervention did not improve WM integrity at group level analysis, individual cardiorespiratory fitness gains were associated with improved WM tract integrity of the prefrontal cortex. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|