Common Genotypes of Hepatitis B virus prevalent in Injecting drug abusers (addicts) of North West Frontier Province of Pakistan
| Autor: | Syed Sohail Zahoor Zaidi, Shamim Saleha, Asif Naeem, Salmaan Sharif, Shehzad Shaukat, Muhammad Masroor Alam, Mehar Angez, Javed Aslam Butt, Salman Akbar Malik |
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| Jazyk: | angličtina |
| Předmět: |
Drug
Adult Male HBsAg medicine.medical_specialty Hepatitis B virus Adolescent Genotype media_common.quotation_subject Enzyme-Linked Immunosorbent Assay medicine.disease_cause lcsh:Infectious and parasitic diseases Virology Epidemiology Medicine Humans Clinical significance Pakistan lcsh:RC109-216 Child Substance Abuse Intravenous media_common Aged Hepatitis B Surface Antigens business.industry Transmission (medicine) Research Hepatitis B Middle Aged medicine.disease Infectious Diseases DNA Viral Female business |
| Zdroj: | Virology Journal, Vol 4, Iss 1, p 63 (2007) Virology Journal |
| ISSN: | 1743-422X |
| DOI: | 10.1186/1743-422x-4-63 |
| Popis: | Background The epidemiological significance of Hepatitis B virus genotypes has been well established and becoming an essential concern day by day however, much little is known about the mixed infection with more than one Hepatitis B virus genotypes and their clinical relevance. Methods Intravenous drug abusers are considered as a major risk group for the acquisition and transmission of blood borne infections like hepatitis B, however, in Pakistan, no such data has ever been reported about the epidemiology of HBV and its genotypes in Injecting Drug Users. 250 individuals were analyzed for hepatitis B virus genotypes after prior screening with serological assay for the detection of HBsAg. Results 56 (22.4%) individuals were found positive on ELSIA for HBsAg. The genotype distribution was found to be as: genotype D, 62.5%; genotype A, 8.92% while 28.57% individuals were found to be infected with a mixture of genotype A and D. Conclusion There is an urgent need of the time to develop public health care policies with special emphasis towards the control of HBV transmission through high risk groups especially Injecting Drug Users. |
| Databáze: | OpenAIRE |
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