No impact of dietary iodine restriction in short term development of hypothyroidism following fixed dose radioactive iodine therapy for Graves’ disease
| Autor: | Charles Stephen, Regi Oommen, Nihal Thomas, Jubbin Jagan Jacob, Thomas V Paul, Mandalam S. Seshadri |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
urinary iodine/creatinine ratios
medicine.medical_specialty endocrine system endocrine system diseases Endocrinology Diabetes and Metabolism Graves' disease radioactive iodine chemistry.chemical_element Disease Iodine medicine.disease_cause lcsh:Diseases of the endocrine glands. Clinical endocrinology Gastroenterology Autoimmunity Endocrinology Internal medicine medicine Euthyroid lcsh:RC799-869 lcsh:RC648-665 business.industry Incidence (epidemiology) Thyroid graves′ disease medicine.disease graves’ disease Surgery medicine.anatomical_structure chemistry Dietary iodine restriction Dietary Iodine lcsh:Diseases of the digestive system. Gastroenterology Original Article business |
| Zdroj: | Indian Journal of Endocrinology and Metabolism Indian Journal of Endocrinology and Metabolism, Vol 19, Iss 1, Pp 60-65 (2015) |
| ISSN: | 2230-9500 2230-8210 |
| Popis: | Background: The increased incidence of autoimmune thyroid disease with increasing dietary iodine intake has been demonstrated both epidemiologically and experimentally. The hypothyroidism that occurs in the first year following radioactive iodine therapy is probably related to the destructive effects of the radiation and underlying ongoing autoimmunity. Objective: To study the outcomes at the end of six months after fixed dose I, 131 therapy for Graves′ disease followed by an iodine restricted diet for a period of six months. Materials and Methods: Consecutive adult patients with Graves′ disease planned for I 131 therapy were randomized either to receive instructions regarding dietary iodine restriction or no advice prior to fixed dose (5mCi) I 131 administration. Thyroid functions and urinary iodine indices were evaluated at 3 rd and 6 th month subsequently. Results: Forty seven patients (13M and 34F) were assessed, 2 were excluded, 45 were randomized (Cases 24 and Controls 21) and 39 patients completed the study. Baseline data was comparable. Median urinary iodine concentration was 115 and 273 μg/gm creat (p = 0.00) among cases and controls respectively. Outcomes at the 3 rd month were as follows (cases and controls); Euthyroid (10 and 6: P = 0.24), Hypothyroid (3 and 5: P = 0.38) and Hyperthyroid (7 and 8: P = 0.64). Outcomes at the end of six months were as follows (cases and controls); Euthyroid (10 and 5: P = 0.12), Hypothyroid (3 and 5: P = 0.38) and Hyperthyroid (7 and 9: P = 0.43). Of the hypothyroid patients 5 (cases 1 and controls 4: P = 0.13) required thyroxine replacement. Conclusions: There was no statistical significant difference in the outcome of patients with dietary iodine restriction following I 131 therapy for Graves′ disease. |
| Databáze: | OpenAIRE |
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