Combination of polymorphisms in luteinizing hormone β, estrogen receptor β and progesterone receptor and susceptibility to infertility and endometriosis
| Autor: | Caio Parente Barbosa, Denise Maria Christofolini, Fernanda Abani Mafra, Bianca Bianco, Gustavo Mendonça André, Fabia Lima Vilarino |
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| Rok vydání: | 2011 |
| Předmět: |
Adult
Infertility medicine.medical_specialty medicine.drug_class Endometriosis Estrogen receptor Polymorphism (computer science) Internal medicine Progesterone receptor medicine Estrogen Receptor beta Humans Genetic Predisposition to Disease Estrogen receptor beta Polymorphism Genetic business.industry Obstetrics and Gynecology Luteinizing Hormone beta Subunit medicine.disease Endocrinology Reproductive Medicine Estrogen Case-Control Studies Female Receptors Progesterone business Infertility Female Estrogen receptor alpha |
| Zdroj: | European Journal of Obstetrics & Gynecology and Reproductive Biology. 158:260-264 |
| ISSN: | 0301-2115 |
| Popis: | Objectives To determine whether the combination of PR (PROGINS), ERβ G + 1730A and/or LHβ G1502A polymorphisms in infertile women with and without endometriosis and in a control group increases the risk of infertility and/or endometriosis. Study design Case-control study including 201 infertile women with endometriosis, 80 infertile women without endometriosis and 206 fertile women as control group. PROGINS was identified by PCR (polymerase chain reaction) and ERβ G + 1730A and LHβ G1502A were identified by PCR-RFLP (restriction fragment length polymorphism). Results A statistically significant difference was found for the combination of LHβ + ERβ polymorphisms among infertile patients with endometriosis and control group (p = 0.003, OR = 2.468), among infertile patients with endometriosis I/II and control group (p = 0.002, OR = 3.081), among infertile patients with endometriosis III/IV and control group (p = 0.035, OR = 2.136) and for the combination of LHβ + PROGINS polymorphisms among infertile patients with endometriosis I/II and control group (p = 0.014, OR = 3.081). However, the odds of developing endometriosis are not enhanced in the presence of the two polymorphisms, being similar to the odds when only LH polymorphism is present. Conclusions Individually, the presence of LHβ G1502A and ERβ G + 1730A polymorphisms is associated with infertility and endometriosis associated infertility. However, when two polymorphisms are present in the same individual it does not appear to increase the chance of developing endometriosis or infertility. |
| Databáze: | OpenAIRE |
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