Bioelectric signaling and the control of cardiac cell identity in response to mechanical forces
| Autor: | Nicolas Minc, Choon Hwai Yap, Naoki Mochizuki, Hajime Fukui, Yoke Yin Foo, Julien Vermot, Renee Wei-Yan Chow, Jing Xie |
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| Přispěvatelé: | Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), National cerebral and cardiovascular center research institute, Institut Jacques Monod (IJM (UMR_7592)), Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), National University of Singapore (NUS), Imperial College London, ANR-15-CE13-0015,liveheart,Etude des bases cellulaires du développement et de la régénération cardiaque par une approche d'imagerie in vivo(2015), ANR-10-IDEX-0002,UNISTRA,Par-delà les frontières, l'Université de Strasbourg(2010), ANR-12-ISV2-0001,charon,Analyse quantitative de l'expression asymétrique du gene Charon en réponse au flux ciliaire dans l'organiseur droite gauche.(2012), ANR-10-LABX-0030,INRT,Integrative Biology : Nuclear dynamics- Regenerative medicine - Translational medicine(2010), European Project: 682938,EVALVE, European Project: 647073,H2020,ERC-2014-CoG,FORCASTER(2015) |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Multidisciplinary
NFATC Transcription Factors Receptors Purinergic P2 [SDV]Life Sciences [q-bio] Identity (social science) Endothelial Cells Heart Valves Cardiac cell Electrophysiological Phenomena Adenosine Triphosphate Animals Calcium Calcium Signaling Stress Mechanical Psychology Control (linguistics) Shear Strength Neuroscience Zebrafish |
| Zdroj: | Science Science, 2021, 374 (6565), pp.351-354. ⟨10.1126/science.abc6229⟩ |
| ISSN: | 0036-8075 1095-9203 |
| DOI: | 10.1126/science.abc6229⟩ |
| Popis: | Making cardiac valves via mechanical forces Cardiac valves form in response to mechanical forces generated by the beating heart. Fukui et al . studied how patterning signals are generated in response to these forces (see the Perspective by Jain and Epstein). They show that two mechanotransduction pathways act in parallel to instruct cardiac valve progenitors: a well-established transient receptor potential mechanosensation pathway and an extracellular ATP-dependent purinergic receptor pathway that triggers Ca 2+ oscillations and results in nuclear translocation of the protein nuclear factor of activated T cells 1. These two synergistic mechanotransduction pathways generate positional information and control valve formation. The use of multiple pathways may be a general mechanism used by mechanosensitive biological systems to increase the robustness and precision of mechanotransduction. —BAP |
| Databáze: | OpenAIRE |
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