Myelodysplasia in Children: Report of 2 Cases

Autor:	Vanesa John, M. C. Savithri, K. P. Kavitha
Rok vydání:	2013
Předmět:	Pediatrics medicine.medical_specialty Hematology business.industry Bone marrow failure Case Report Macrocytosis medicine.disease Pancytopenia Human genetics Fanconi anemia hemic and lymphatic diseases Internal medicine medicine business
Zdroj:	Indian Journal of Hematology and Blood Transfusion. 30:151-153
ISSN:	0974-0449 0971-4502
DOI:	10.1007/s12288-013-0304-x
Popis:	Myelodysplasia in children is rare. We report two cases presenting with pancytopaenia and macrocytosis with additional features suggestive of Fanconi anemia which is an autosomal recessive disorder in which there is progressive bone marrow failure and increased predisposition to malignancies especially AML. Hypersensitivity of FA cells to the chromosome-breaking effect of cross-linking agents provides a reliable cellular marker for the diagnosis of this disorder.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2269327e944c0d7766026b67fdd2b63a https://doi.org/10.1007/s12288-013-0304-x Zobrazit plný text záznamu Full text from SpringerLink