The effect of pentoxifylline and its metabolite-1 on inflammation and fibrosis in the TNBS model of colitis
| Autor: | Marc R. Peterson, Theresa C. Peterson, Jennifer M. Raoul |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
medicine.medical_specialty
Time Factors Colon Metabolite Inflammation Gastroenterology Collagen Type I Pentoxifylline Rats Sprague-Dawley 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Fibrosis In vivo Internal medicine medicine Animals Colitis Intestinal Mucosa Sirius Red 030304 developmental biology Peroxidase Pharmacology 0303 health sciences business.industry Interleukin-18 Stereoisomerism Organ Size medicine.disease digestive system diseases 3. Good health Rats Intestines Disease Models Animal chemistry Trinitrobenzenesulfonic Acid Immunology 030211 gastroenterology & hepatology Interleukin 18 Female medicine.symptom business medicine.drug |
| Zdroj: | European journal of pharmacology. 662(1-3) |
| ISSN: | 1879-0712 |
| Popis: | TNBS-induced colitis has characteristics resembling human Crohn's disease including transmural inflammation, ulceration, and fibrosis. Current treatments target acute symptoms but do not necessarily prevent fibrotic complications of the disease. The aim of this study was to determine the effect of pentoxifylline and its primary metabolite (M-1) on fibrosis in the TNBS-induced colitis model. Myeloperoxidase activity and interleukin-18 are indicators of inflammation and were elevated in the TNBS model. The morphology damage score assesses colon damage and was also elevated in the TNBS model. Collagen as the indicator of fibrosis was quantified and visualized by the Sirius Red/Fast Green staining technique and collagen type I was assessed by Western analysis. Collagen was elevated in the TNBS-induced model. Pentoxifylline and M-1 treatment significantly attenuated colon damage and inflammation in TNBS-colitis (P |
| Databáze: | OpenAIRE |
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