Hypoglycemia Associated with Extrapancreatic Tumors
| Autor: | Eleazar Shafrir, Shemuel Nissan, Adoniram Bar-Maor |
|---|---|
| Rok vydání: | 1968 |
| Předmět: |
Adult
Blood Glucose Male medicine.medical_specialty Adolescent Epinephrine Glucose uptake Fatty Acids Nonesterified Hypoglycemia chemistry.chemical_compound Serum free Internal medicine medicine Humans Insulin Amino Acids Neoplasm Metastasis Peritoneal Neoplasms Fatty acid metabolism business.industry Lymphoma Non-Hodgkin Liver Neoplasms Mesenchymal stem cell General Medicine medicine.disease Lipids In vitro Glucose Endocrinology Liver Gluconeogenesis chemistry Growth Hormone Lactates Female Lymphoma Large B-Cell Diffuse business Omentum medicine.drug |
| Zdroj: | New England Journal of Medicine. 278:177-183 |
| ISSN: | 1533-4406 0028-4793 |
| DOI: | 10.1056/nejm196801252780402 |
| Popis: | Two patients had hypoglycemia associated with large and diffuse mesenchymal abdominal tumors. In these, the pattern of changes in blood glucose and free fatty acids after a glucose load or epinephrine injection, high plasma lactate levels, low serum insulin and insulin-like activity and excessive glucose uptake by tumor tissue in vitro indicated that the primary cause of hypoglycemia was enhanced glucose dissimilation by the large mass of the tumor. Deficient compensatory glucogenesis might have been a contributing factor. Divergent patterns of the response of serum free fatty acids to epinephrine injection were related to insulin-dependent and independent hypoglycemia. |
| Databáze: | OpenAIRE |
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