Oxygenated Water Inhibits Adipogenesis and Attenuates Hepatic Steatosis in High-Fat Diet-Induced Obese Mice

Autor: Hsueh Te Lee, Yih Hsin Chang, Jen Ning Tsai, Ching-Ping Yang, Ming Yuh Shiau, Yuh-Jen Cheng, Cheng-Wei Chuang, Chao-Chi Liu, Chiao-Wan Hsiao, Fang-Yeh Chu
Jazyk: angličtina
Rok vydání: 2020
Předmět:
0301 basic medicine
Mice
Obese
Adipose tissue
lcsh:Chemistry
Mice
chemistry.chemical_compound
0302 clinical medicine
Fibrosis
Adipocyte
lipid metabolism
lcsh:QH301-705.5
Spectroscopy
hepatic steatosis
Cell Differentiation
General Medicine
Computer Science Applications
Adipose Tissue
Adipogenesis
oxygenated water
medicine.symptom
medicine.medical_specialty
adipocytes
030209 endocrinology & metabolism
Inflammation
Diet
High-Fat
Article
Catalysis
adipogenesis
Inorganic Chemistry
03 medical and health sciences
3T3-L1 Cells
Internal medicine
medicine
Animals
Humans
Obesity
Physical and Theoretical Chemistry
Molecular Biology
Lipogenesis
Organic Chemistry
Water
Lipid metabolism
medicine.disease
Fatty Liver
Oxygen
030104 developmental biology
Endocrinology
chemistry
lcsh:Biology (General)
lcsh:QD1-999
Steatosis
Adipocyte hypertrophy
Zdroj: International Journal of Molecular Sciences, Vol 21, Iss 5493, p 5493 (2020)
International Journal of Molecular Sciences
Volume 21
Issue 15
ISSN: 1661-6596
1422-0067
Popis: The expansion of adipose tissue mass is the primary characteristic of the process of becoming obesity, which causes chronic adipose inflammation and is closely associated with type 2 diabetes mellitus (T2DM). Adipocyte hypertrophy restricts oxygen availability, leading to microenvironmental hypoxia and adipose dysfunction. This study aimed at investigating the effects of oxygenated water (OW) on adipocyte differentiation (adipogenesis) and the metabolic function of mature adipocytes. The effects of OW on adipogenesis and the metabolic function of mature adipocytes were examined. Meanwhile, the in vivo metabolic effects of long-term OW consumption on diet-induced obesity (DIO) mice were investigated. OW inhibited adipogenesis and lipid accumulation through down-regulating critical adipogenic transcription factors and lipogenic enzymes. While body weight, blood and adipose parameters were not significantly improved by long-term OW consumption, transient circulatory triglyceride-lowering and glucose tolerance-improving effects were identified. Notably, hepatic lipid contents were significantly reduced, indicating that the DIO-induced hepatic steatosis was attenuated, despite no improvements in fibrosis and lipid contents in adipose tissue being observed in the OW-drinking DIO mice. The study provides evidence regarding OW&rsquo
s effects on adipogenesis and mature adipocytes, and the corresponding molecular mechanisms. OW exhibits transient triglyceride-lowering and glucose tolerance-improving activity as well as hepatic steatosis-attenuating functions.
Databáze: OpenAIRE
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