Oxygenated Water Inhibits Adipogenesis and Attenuates Hepatic Steatosis in High-Fat Diet-Induced Obese Mice
Autor: | Hsueh Te Lee, Yih Hsin Chang, Jen Ning Tsai, Ching-Ping Yang, Ming Yuh Shiau, Yuh-Jen Cheng, Cheng-Wei Chuang, Chao-Chi Liu, Chiao-Wan Hsiao, Fang-Yeh Chu |
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Jazyk: | angličtina |
Rok vydání: | 2020 |
Předmět: |
0301 basic medicine
Mice Obese Adipose tissue lcsh:Chemistry Mice chemistry.chemical_compound 0302 clinical medicine Fibrosis Adipocyte lipid metabolism lcsh:QH301-705.5 Spectroscopy hepatic steatosis Cell Differentiation General Medicine Computer Science Applications Adipose Tissue Adipogenesis oxygenated water medicine.symptom medicine.medical_specialty adipocytes 030209 endocrinology & metabolism Inflammation Diet High-Fat Article Catalysis adipogenesis Inorganic Chemistry 03 medical and health sciences 3T3-L1 Cells Internal medicine medicine Animals Humans Obesity Physical and Theoretical Chemistry Molecular Biology Lipogenesis Organic Chemistry Water Lipid metabolism medicine.disease Fatty Liver Oxygen 030104 developmental biology Endocrinology chemistry lcsh:Biology (General) lcsh:QD1-999 Steatosis Adipocyte hypertrophy |
Zdroj: | International Journal of Molecular Sciences, Vol 21, Iss 5493, p 5493 (2020) International Journal of Molecular Sciences Volume 21 Issue 15 |
ISSN: | 1661-6596 1422-0067 |
Popis: | The expansion of adipose tissue mass is the primary characteristic of the process of becoming obesity, which causes chronic adipose inflammation and is closely associated with type 2 diabetes mellitus (T2DM). Adipocyte hypertrophy restricts oxygen availability, leading to microenvironmental hypoxia and adipose dysfunction. This study aimed at investigating the effects of oxygenated water (OW) on adipocyte differentiation (adipogenesis) and the metabolic function of mature adipocytes. The effects of OW on adipogenesis and the metabolic function of mature adipocytes were examined. Meanwhile, the in vivo metabolic effects of long-term OW consumption on diet-induced obesity (DIO) mice were investigated. OW inhibited adipogenesis and lipid accumulation through down-regulating critical adipogenic transcription factors and lipogenic enzymes. While body weight, blood and adipose parameters were not significantly improved by long-term OW consumption, transient circulatory triglyceride-lowering and glucose tolerance-improving effects were identified. Notably, hepatic lipid contents were significantly reduced, indicating that the DIO-induced hepatic steatosis was attenuated, despite no improvements in fibrosis and lipid contents in adipose tissue being observed in the OW-drinking DIO mice. The study provides evidence regarding OW&rsquo s effects on adipogenesis and mature adipocytes, and the corresponding molecular mechanisms. OW exhibits transient triglyceride-lowering and glucose tolerance-improving activity as well as hepatic steatosis-attenuating functions. |
Databáze: | OpenAIRE |
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