84 COVID-19 and Associations with Frailty and Multimorbidity: A Prospective Analysis of UK Biobank Participants
| Autor: | Hansa Patel, Elaine M. Dennison, S. J. Woolford, Elizabeth M Curtis, Camille Parsons, Stefania D'Angelo, K A Ward, C Cooper, Nicholas C. Harvey |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Gerontology
Aging Coronavirus disease 2019 (COVID-19) business.industry Ethnic group Posters Scientific Presentation: Epid (Epidemiology) General Medicine Disease medicine.disease Logistic regression Biobank Comorbidity Preferred walking speed Abstracts AcademicSubjects/MED00280 medicine Multimorbidity Geriatrics and Gerontology business |
| Zdroj: | Age and Ageing |
| ISSN: | 1468-2834 0002-0729 |
| Popis: | Introduction Frailty and multimorbidity have been suggested as risk factors for severe COVID-19 disease. We therefore investigated whether frailty and multimorbidity were associated with risk of hospitalisation with COVID-19 in the UK Biobank. Method 502,640 participants aged 40–69 years at baseline (54–79 years at COVID-19 testing) were recruited across UK 2006–10. A modified assessment of frailty using Fried’s classification was generated from baseline data. COVID-19 test results (England) were available 16/03/2020–01/06/2020, mostly taken in hospital settings. Logistic regression was used to discern associations between frailty, multimorbidity and COVID-19 diagnoses, adjusting for sex, age, BMI, ethnicity, education, smoking and number of comorbidity groupings, comparing COVID-19 positive, COVID-19 negative and non-tested groups. Results 4,510 participants were tested for COVID-19 (positive = 1,326, negative = 3,184). 497,996 participants were not tested. Compared to the non-tested group, after adjustment, COVID-19 positive participants were more likely to be frail (OR = 1.4 [95%CI = 1.1, 1.8]), report slow walking speed (OR = 1.3 [1.1, 1.6]), report two or more falls in the past year (OR = 1.3 [1.0, 1.5]) and be multimorbid (≥4 comorbidity groupings vs 0–1: OR = 1.9 [1.5, 2.3]). However, similar strength of associations were apparent when comparing COVID-19 negative and non-tested groups. Furthermore, frailty and multimorbidity were not associated with COVID-19 diagnoses, when comparing COVID-19 positive and COVID-19 negative participants. Conclusions Frailty and multimorbidity do not appear to aid risk stratification, in terms of a positive versus negative results of COVID-19 testing. Investigation of the prognostic value of these markers for adverse clinical sequelae following COVID-19 disease is urgently needed. |
| Databáze: | OpenAIRE |
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