Compound A Concentrations During Low-Flow Sevoflurane Anesthesia Correlate Directly with the Concentration of Monovalent Bases in Carbon Dioxide Absorbents
| Autor: | Hideyuki Higuchi, Yushi U. Adachi, Tetsuo Satoh, Shinya Arimura, Masuyuki Kanno |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Compound a
Potassium hydroxide Calcium hydroxide business.industry chemistry.chemical_element Calcium Sevoflurane chemistry.chemical_compound Anesthesiology and Pain Medicine chemistry Sodium hydroxide Anesthesia Carbon dioxide medicine business medicine.drug Nuclear chemistry Sevoflurane anesthesia |
| Zdroj: | Anesthesia & Analgesia. 91:434-439 |
| ISSN: | 0003-2999 |
| DOI: | 10.1213/00000539-200008000-00039 |
| Popis: | UNLABELLED Sevoflurane degrades to Compound A, which is nephrotoxic in rats. Potassium hydroxide (KOH) and sodium hydroxide (NaOH) are primary determinants of this degradation reaction. To address this, new carbon dioxide absorbents, such as Amsorb((R)) (A; Armstrong Medical, Coleraine, Northern Ireland), which contains neither KOH nor NaOH, Dragersorb 800 Plus((R)) (D; Drager, Luebeck, Germany), and Medisorb((R)) (M; Datex-Ohmeda, Bromma, Sweden), which contain some NaOH (1% to 2%) and only trace amounts of KOH (0.003%), were recently developed. We compared Compound A concentrations using these three CO(2) absorbents during low-flow (1 L/min) sevoflurane anesthesia in surgical patients, with those using a conventional CO(2) absorbent, Dragersorb 800 (C). The mean Compound A concentrations +/- SD using C, A, D, and M were 18.7 +/- 2.5, 1.8 +/- 0.7, 13.3 +/- 3.5, and 11.2 +/- 2.6 ppm, respectively, with significant differences (P < 0.001; A versus C, A versus D, A versus M, C versus D, C versus M). Amsorb prevented the degradation of sevoflurane to Compound A, whereas Dragersorb 800 Plus and Medisorb decreased the degradation to Compound A. IMPLICATIONS Sevoflurane degradation to Compound A is decreased by lowering the concentration of monovalent bases in the carbon dioxide absorbent (Dragersorb 800 Plus) [Drager, Luebeck, Germany] and Medisorb) [Datex-Ohmeda, Bromma, Sweden]) and is virtually eliminated in the absence of these bases (Amsorb) [Armstrong Medical, Coleraine, Northern Ireland]). |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|