Correlation between apparent diffusion coefficient and histopathology subtypes of osteosarcoma after neoadjuvant chemotherapy
| Autor: | Quan-Fei Meng, Margaret H Pui, Jifei Wang, Meili Sun, Zhenhua Gao, Da-Wei Liu, Xiao-shu Hu |
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| Rok vydání: | 2016 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent medicine.medical_treatment Bone Neoplasms 030218 nuclear medicine & medical imaging 03 medical and health sciences 0302 clinical medicine Antineoplastic Combined Chemotherapy Protocols medicine Effective diffusion coefficient Humans Radiology Nuclear Medicine and imaging Ifosfamide Child Chemotherapy Osteosarcoma Radiological and Ultrasound Technology medicine.diagnostic_test business.industry Magnetic resonance imaging General Medicine medicine.disease Limb Salvage Neoadjuvant Therapy body regions Diffusion Magnetic Resonance Imaging Methotrexate Treatment Outcome Doxorubicin 030220 oncology & carcinogenesis Histopathology Female Radiology Cisplatin business |
| Zdroj: | Acta radiologica (Stockholm, Sweden : 1987). 58(8) |
| ISSN: | 1600-0455 |
| Popis: | Background Neoadjuvant chemotherapy has made limb-salvage surgery possible for the patients with osteosarcoma. Diffusion-weighted magnetic resonance imaging (DWI) has been used to monitor chemotherapy response. Purpose To correlate the apparent diffusion coefficient (ADC) values with histopathology subtypes of osteosarcoma after neoadjuvant chemotherapy. Material and Methods Twelve patients with osteoblastic (n = 7), chondroblastic (n = 4), and fibroblastic (n = 1) osteosarcomas underwent post-chemotherapy DWI before limb-salvage surgery. ADCs corresponding to 127 histological tissue samples from the 12 resected specimens were compared to histological features. Results The mean ADC value of non-cartilaginous viable tumor (38/91, ADC = 1.22 ± 0.03 × 10−3 mm2/s) was significantly ( P −3 mm2/s), cartilaginous viable tumor (14/91, ADC = 2.19 ± 0.04 × 10−3 mm2/s), and cystic areas including liquefied necrosis, blood space, and secondary aneurysmal bone cyst (14/91, ADC = 2.29 ± 0.05 × 10−3 mm2/s). The mean ADC value of non-cartilaginous tumor cell necrosis was also significantly ( P 0.05) different between viable cartilaginous tumor and cystic/hemorrhagic necrosis. Conclusion DWI allows assessment of tumor necrosis after neoadjuvant chemotherapy by ADC differences between viable tumor and necrosis in fibroblastic and osteoblastic osteosarcomas whereas viable chondroblastic osteosarcoma has high ADC and cannot be distinguished reliably from necrosis. |
| Databáze: | OpenAIRE |
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