A Role for Both V1a and V2 Receptors in Renal Heat Stress Injury Amplified by Rehydration with Fructose

Autor: Edilia Tapia, L. Gabriela Sánchez-Lozada, Fernando E. García-Arroyo, Alison Iroz, Horacio Osorio-Alonso, Guillermo Gonzaga, Carlos A. Roncal-Jimenez, Juan G. Reyes-García, Itzel Muñoz-Jiménez, Richard J. Johnson, Mariacristina Vecchio
Rok vydání: 2019
Předmět:
Male
Vasopressin
Receptors
Vasopressin
Indoles
Pyrrolidines
Hydrocortisone
vasopressin
030232 urology & nephrology
030204 cardiovascular system & hematology
angiotensin II
medicine.disease_cause
lcsh:Chemistry
Renin-Angiotensin System
0302 clinical medicine
Arginine vasopressin receptor 2
SGK1
Receptor
lcsh:QH301-705.5
Spectroscopy
Vasopressin receptor
Chemistry
fructokinase
Temperature
General Medicine
aldose reductase
Computer Science Applications
Up-Regulation
Vasopressin secretion
medicine.medical_specialty
Kidney Cortex
Fructose
Protein Serine-Threonine Kinases
cortisol
Catalysis
Article
Immediate-Early Proteins
Inorganic Chemistry
Beverages
03 medical and health sciences
Internal medicine
medicine
Animals
Physical and Theoretical Chemistry
Rats
Wistar
Renal Insufficiency
Chronic
Molecular Biology
Organic Chemistry
Angiotensin II
Rats
Oxidative Stress
Endocrinology
lcsh:Biology (General)
lcsh:QD1-999
Tolvaptan
Fluid Therapy
Oxidative stress
Heat-Shock Response
Zdroj: International Journal of Molecular Sciences
Volume 20
Issue 22
International Journal of Molecular Sciences, Vol 20, Iss 22, p 5764 (2019)
ISSN: 1422-0067
Popis: Chronic vasopressin secretion induced by recurrent mild heat stress exposure is significantly enhanced by limited rehydration with a fructose-containing beverage both in rodents and in humans. Moreover, this effect has been associated with upregulation of the polyol&ndash
fructokinase pathway and increased renal oxidative stress. Previously, we have shown that pharmacological inhibition of both V1a and V2 vasopressin receptors with conivaptan improved such renal alterations. The aim of this study was to evaluate the independent contributions of V1a and V2 receptors to the renal damage caused by mild heat stress and limited rehydration with a fructose-containing beverage. Osmotic minipumps were used to deliver either relcovaptan (0.64 mg/day) or tolvaptan (0.25 mg/day) in male Wistar rats for two weeks. Corresponding dilution vehicles were used as controls. To induce dehydration, rats were exposed to mild heat stress (37 °
C for 1 h, Monday to Friday). All groups received a 10% fructose solution as a rehydration fluid for 2 h after mild heat stress. For the remainder of the day and on weekends, rats received tap water. The independent blockade of either the V1a or the V2 receptor prevented renal damage, reduced oxidative stress, and decreased plasma cortisol and systemic inflammation. However, the beneficial effects were regulated by different mechanisms. Tolvaptan inhibited polyol&ndash
fructokinase pathway overactivation, while relcovaptan prevented upregulation of the renin&ndash
angiotensin system and SGK1 expression. These data suggest that both V1a and V2 receptors participate in renal damage caused by heat stress-induced dehydration when fructose-containing beverages are used as rehydration fluids.
Databáze: OpenAIRE
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