Iron‐Catalyzed Borrowing Hydrogen C‐Alkylation of Oxindoles with Alcohols
| Autor: | Mubarak B. Dambatta, Kurt Polidano, Alexander D. Northey, Louis C. Morrill, Jonathan M. J. Williams |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
borrowing hydrogen
010405 organic chemistry Chemistry General Chemical Engineering Iron catalyzed Communication Borrowing hydrogen Alkylation 010402 general chemistry 01 natural sciences Medicinal chemistry Communications 0104 chemical sciences alcohols chemistry.chemical_compound General Energy Cyclopentadienone Yield (chemistry) Environmental Chemistry General Materials Science alkylation oxindoles iron catalysis |
| Zdroj: | Chemsuschem |
| ISSN: | 1864-564X 1864-5631 |
| Popis: | A general and efficient iron‐catalyzed C‐alkylation of oxindoles has been developed. This borrowing hydrogen approach employing a (cyclopentadienone)iron carbonyl complex (2 mol %) exhibited a broad reaction scope, allowing benzylic and simple primary and secondary aliphatic alcohols to be employed as alkylating agents. A variety of oxindoles underwent selective mono‐C3‐alkylation in good‐to‐excellent isolated yields (28 examples, 50–92 % yield, 79 % average yield). |
| Databáze: | OpenAIRE |
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