Direct Activation of the C(sp3)–NH2 Bond of Primary Aliphatic Alkylamines by a High-Valent CoIII,IV2(μ-O)2 Diamond Core Complex
| Autor: | Yan Li, Suhashini Handunneththige, Jin Xiong, Yisong Guo, Marat R. Talipov, Dong Wang |
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| Rok vydání: | 2023 |
| Předmět: | |
| Zdroj: | J Am Chem Soc |
| ISSN: | 1520-5126 0002-7863 |
| Popis: | Aliphatic alkylamines are abundant feedstock and versatile building blocks for many organic transformations. While remarkable progress has been made to construct C–N bonds on aliphatic and aromatic carbon centers, the activation and functionalization of C(sp(3))–NH(2) bonds in primary alkylamines remain a challenging process. In the present work, we discovered an unprecedented method to directly activate the C(sp(3))–NH(2) bond of primary alkylamines by a high-valent dinuclear Co(III,IV)(2)(μ-O)(2) diamond core complex. This reaction results in the installation of other functional groups such as halides and alkene onto the α-carbon center concomitant with the 2-e(−) oxidation of the nitrogen atom on the amino group to form NH(2)OH. Our results shed light on future development of catalytic systems enabling versatile functionalization of primary alkylamines based on the dinuclear cobalt system. |
| Databáze: | OpenAIRE |
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