Back to the future: Rational maps for exploring acetylcholine receptor space and time
| Autor: | Christian J.G. Tessier, F. Javier Pérez-Areales, Johnathon R. Emlaw, Corrie J.B. daCosta, Jean-Paul J. Salameh, Melissa McNulty, Zhuo Qian Cao, Jethro E. Prinston |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Protein subunit Patch clamp electrophysiology Biophysics Cooperativity Computational biology Biology Biochemistry Analytical Chemistry Evolution Molecular 03 medical and health sciences Structure-Activity Relationship 0302 clinical medicine Animals Humans Receptors Cholinergic Amino acid residue Molecular Biology Acetylcholine receptor chemistry.chemical_classification Amino acid Structure and function Protein Structure Tertiary 030104 developmental biology Nicotinic agonist chemistry 030217 neurology & neurosurgery |
| Zdroj: | Biochimica et biophysica acta. Proteins and proteomics. 1865(11 Pt) |
| ISSN: | 1570-9639 |
| Popis: | Global functions of nicotinic acetylcholine receptors, such as subunit cooperativity and compatibility, likely emerge from a network of amino acid residues distributed across the entire pentameric complex. Identification of such networks has stymied traditional approaches to acetylcholine receptor structure and function, likely due to the cryptic interdependency of their underlying amino acid residues. An emerging evolutionary biochemistry approach, which traces the evolutionary history of acetylcholine receptor subunits, allows for rational mapping of acetylcholine receptor sequence space, and offers new hope for uncovering the amino acid origins of these enigmatic properties. |
| Databáze: | OpenAIRE |
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