Research Progress of Quercetin Delivery Systems

Autor: Xingtao Zhao, Ying Deng, Xinyan Xue, Li Liao, Mengting Zhou, Cheng Peng, Yunxia Li
Rok vydání: 2022
Předmět:
Zdroj: Current Pharmaceutical Design. 28:727-742
ISSN: 1381-6128
Popis: Quercetin is the main dietary flavonoid with a wide range of pharmacological activities. However, the poor gastrointestinal absorption and low bioavailability of quercetin curtail its clinical applications.We performed a systematic research on the quercetin drug delivery system in PubMed, Web of Science, SciFinder, Google Scholar, Chinese National Knowledge Infrastructure database, and summarized it reasonably.The bioavailability of quercetin can be improved through the application of delivery systems technologies, such as microparticle delivery systems, solid dispersions, encapsulation, phospholipid complexes, and hydrogels. Quercetin delivery systems have been demonstrated to exhibit stronger antibacterial, anti-oxidant, anti-inflammatory, anti-cancer, and other pharmacological effects in vitro and in vivo animal experiments, promoting the development and optimization of quercetin delivery systems for clinical applications.
Databáze: OpenAIRE