Two-year outcome after biodegradable polymer sirolimus- and biolimus- eluting coronary stents:From the randomized SORT OUT VII trial

Autor: Evald Høj Christiansen, Bent Raungaard, Johnny Kahlert, Henrik Steen Hansen, Knud Nørregaard Hansen, Michael Maeng, Hans Erik Bøtker, Lisette Okkels Jensen, Svend Eggert Jensen, Jens Flensted Lassen
Jazyk: angličtina
Rok vydání: 2018
Předmět:
medicine.medical_specialty
Time Factors
Polymers
medicine.medical_treatment
Coronary Artery Disease
030204 cardiovascular system & hematology
Sirolimus/administration & dosage
Prosthesis Design
Outcome (game theory)
Coronary artery disease
03 medical and health sciences
0302 clinical medicine
Percutaneous Coronary Intervention
Coronary thrombosis
Coated Materials
Biocompatible
Risk Factors
Coronary Thrombosis/epidemiology
Absorbable Implants
medicine
Journal Article
Humans
030212 general & internal medicine
Percutaneous Coronary Intervention/adverse effects
Sirolimus
business.industry
Coronary Thrombosis
Percutaneous coronary intervention
Cardiovascular Agents
Drug-Eluting Stents
medicine.disease
Biodegradable polymer
Surgery
Treatment Outcome
Cardiovascular agent
Cardiovascular Agents/administration & dosage
Cardiology and Cardiovascular Medicine
business
Coronary Artery Disease/diagnostic imaging
medicine.drug
Zdroj: Jensen, L O, Maeng, M, Raungaard, B, Hansen, K N, Kahlert, J, Jensen, S E, Hansen, H S, Lassen, J F, Bøtker, H E & Christiansen, E H 2018, ' Two-year outcome after biodegradable polymer sirolimus-and biolimus-eluting coronary stents : From the randomized SORT OUT VII trial ', EuroIntervention, vol. 13, no. 13, pp. 1587-1590 . https://doi.org/10.4244/EIJ-D-17-00731
Jensen, L O, Maeng, M, Raungaard, B, Hansen, K N, Kahlert, J, Jensen, S E, Hansen, H S, Lassen, J F, Bøtker, H E & Christiansen, E H 2018, ' Two-year outcome after biodegradable polymer sirolimusand biolimus-eluting coronary stents (from the randomised SORT OUT VII trial) ', EuroIntervention, vol. 13, no. 13, pp. 1587-1590 . https://doi.org/10.4244/EIJ-D-17-00731
DOI: 10.4244/EIJ-D-17-00731
Popis: AIMS: The SORT OUT VII trial compared the thin-strut cobalt-chromium sirolimus-eluting Orsiro stent with a slow polymer degradation and the thicker-strut stainless steel biolimus-eluting Nobori stent with a moderate-term polymer degradation in an all-comer patient population.METHODS AND RESULTS: The 2-year pre-specified endpoint target lesion failure did not differ significantly between the sirolimus-eluting stent: 6.7% and the biolimus-eluting stent: 7.0% (rate ratio (RR) 0.94, 95% confidence interval (CI) 0.70-1.28). Definite stent thrombosis were numerically lower in the sirolimus-eluting stent group (0.8%) compared to the biolimus-eluting stent group (1.4%) (RR 0.56, 95% CI 0.26-1.21), which largely was attributable to a lower risk of definite stent thrombosis within 1 year: 0.4% versus 1.2% (RR 0.33, 95% CI 0.12-0.92), whereas risk of very late definite stent thrombosis was similar in the two groups (0.4% versus 0.2%, RR 1.68, 95% CI 0.40-7.03).CONCLUSIONS: In an all-comer patient population, 2-year target lesions failure was similar for the sirolimus-eluting Orsiro stent and the biolimus-eluting Nobori stent.
Databáze: OpenAIRE
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