INOSITOL 1,4,5,-TRISPHOSPHATE PHOSPHATASE DEFICIENCY AND MALIGNANT HYPERPYREXIA IN SWINE
| Autor: | E. Gesini, Paul S. Foster, Michael A. Denborough, K. C. Hopkinson, Charles Claudianos |
|---|---|
| Rok vydání: | 1989 |
| Předmět: |
medicine.medical_specialty
animal structures Swine Inositol Phosphates Phosphatase chemistry.chemical_element Inositol 1 4 5-Trisphosphate Biology Calcium chemistry.chemical_compound Internal medicine Methods medicine Animals Inositol Phosphorylation Endoplasmic reticulum Malignant hyperthermia General Medicine medicine.disease Phosphoric Monoester Hydrolases Sarcoplasmic Reticulum Endocrinology chemistry Sugar Phosphates medicine.symptom Halothane Malignant Hyperthermia Intracellular Muscle Contraction Muscle contraction |
| Zdroj: | The Lancet. 334:124-127 |
| ISSN: | 0140-6736 |
| DOI: | 10.1016/s0140-6736(89)90182-7 |
| Popis: | The sarcoplasmic reticulum from muscle of swine which are susceptible to malignant hyperpyrexia is deficient in inositol 1,4,5-trisphosphate phosphatase (InsP35-ase) activity, which leads to high intracellular concentrations of inositol 1,4,5-trisphosphate (InsP3) and of calcium ions. Halothane inhibits InsP35-ase and further increases myoplasmic InsP3 and calcium ion concentrations, and produces the clinical features of malignant hyperpyrexia. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|