Evaluation of osseous integration of titanium orthopedic screws with novel SLA treatment in porcine model

Autor: Meng Chian Wu, Shu Wei Wu, Hsin Tai Hu, Hsueh Chun Wang, Tzu Hsiang Lin, Ming Long Yeh
Jazyk: angličtina
Rok vydání: 2017
Předmět:
Male
X-ray microtomography
Vertebrae
Swine
Organogenesis
Dentistry
lcsh:Medicine
Bone tissue
0302 clinical medicine
Acid Etching
Dental
Implants
Experimental
Osteogenesis
Animal Cells
Bone cell
Medicine and Health Sciences
lcsh:Science
Musculoskeletal System
Connective Tissue Cells
Titanium
Multidisciplinary
Physics
Dental Implantation
Endosseous
Classical Mechanics
Biomechanical Phenomena
Chemistry
medicine.anatomical_structure
Connective Tissue
Physical Sciences
Swine
Miniature
Engineering and Technology
Anatomy
Cellular Types
Research Article
Chemical Elements
medicine.medical_specialty
Histology
Osseointegration
03 medical and health sciences
Motion
medicine
Cortical Bone
Animals
Tibia
Skeleton
Dental Implants
Bone Development
Osteoblasts
business.industry
Surface Treatments
lcsh:R
Biology and Life Sciences
030206 dentistry
X-Ray Microtomography
Cell Biology
Spine
Biological Tissue
Dental Prosthesis Design
Torque
Manufacturing Processes
Orthopedic surgery
Cortical bone
lcsh:Q
Implant
business
Organism Development
030217 neurology & neurosurgery
Developmental Biology
Zdroj: PLoS ONE, Vol 12, Iss 11, p e0188364 (2017)
PLoS ONE
ISSN: 1932-6203
Popis: The success of many endosseous implants in orthopaedic and dental applications depends on the surface characteristics, as they affect osseous integration. Previous investigations indicated that a novel large-grit sand-blasted and acid-etched (SLA) titanium (denoted as SLAffinity-Ti) implant had better bone integration than that of a comparably shaped implant with a plasma-sprayed titanium surface. The purpose of the present investigation was to create a SLAffinity surface on pedicle screws and trauma screws and to compare it with the surfaces of a sand-blasted-only implant and commercial implants in terms of bone integration. The cortical bone and spine of twelve minipigs were implanted with 3 and 4 implants, respectively, and the bone integration was evaluated using micro-computed tomography (micro-CT), mechanical tests (pull-out strength and stripping torque), and histological analysis (toluidine blue and hematoxylin and eosin staining) one and three months after implantation. The micro-CT images showed that the gap between the bone and implant was consistently higher in the sand-blasted-only and commercial groups compared to that in the SLAffinity group 1 and 3 months after implantation. Moreover, the bone volume of implant inserted into bone and the percentage of implant inside bone tissue were greater in the SLAffinity screws 1 and 3 months after implantation, as compared to the sand-blasted and commercial screws. In the mechanical tests, the removal torque and pull-out strength (p < 0.05) were higher in the SLAffinity group at 1 and 3 months. The histological results were consistent with mechanical testing, showing that the SLAffinity group had the most mineralized matrix, the most bone formation around the screws, and the most bone cells in bone tissue. These findings indicate that a SLAffinity surface can effectively enhance the holding strength and integration of pedicle screws and cortical screws, promoting early healing and improving outcomes, compared to sand-blasted-only and commercial implants.
Databáze: OpenAIRE
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