Ganoderma lucidum Rhodiola compound preparation prevent d-galactose-induced immune impairment and oxidative stress in aging rat model
Autor: | Jiao Li, Shaoheng Li, Liping Liu, Hee-Do Hong, Qinggao Zhang, Yong Yang, Shuo Yuan, Xiaoyu Tan, Yuying Cao |
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Jazyk: | angličtina |
Rok vydání: | 2020 |
Předmět: |
Male
Aging medicine.medical_specialty Reishi Antioxidant medicine.medical_treatment lcsh:Medicine medicine.disease_cause Article Lipofuscin Rats Sprague-Dawley Medical research Internal medicine Rhodiola medicine Splenocyte Animals Hippocampus (mythology) lcsh:Science Multidisciplinary biology Plant Extracts Chemistry lcsh:R Galactose biology.organism_classification Enzyme assay Rats Oxidative Stress Cytokine Endocrinology biology.protein Cytokines lcsh:Q Oxidative stress |
Zdroj: | Scientific Reports, Vol 10, Iss 1, Pp 1-11 (2020) Scientific Reports |
ISSN: | 2045-2322 |
Popis: | Aging is an irreversible process. This research aims to study the anti-aging effects of GRCP, a compound preparation made by Ganoderma lucidum and Rhodiola rosen, in aging rats. Rats were subcutaneously injected with 400 mg/kg of d-galactose daily, and aging could be induced after 8 weeks. The aging rats were treated with GRCP. This experiment was divided into 6 groups. Rats were randomly divided into the model group, positive control group, low-dose GRCP group (25 mg/kg body weight), medium-dose GRCP group (50 mg/kg body weight), and high-dose GRCP group (100 mg/kg body weight), healthy and normal rats were used as blank controls. After the end, the results show that the use of GRCP at a dose of 100 mg/kg is the best treatment for improving aging rats. Rats gained weight, spleen and thymus indexes, and splenocyte proliferation improved, and inflammatory cytokine levels decreased. Besides, biochemical indicators show that GRCP can improve the antioxidant enzyme activity and reduce the content of lipofuscin and TGF-β in aging rats (P |
Databáze: | OpenAIRE |
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