The effects of hypertension and body mass index on diffusion tensor imaging in schizophrenia
| Autor: | Emily Eaves, Lauren Flanagan, Thomas McGinn, Johnny Ng, David Carpenter, Kenneth L. Davis, Stephanie Gottlieb, Leonard White, Erin Moshier, Stephanie Bowler, Michael Parrella, Cheuk Y. Tang, Vladan Novakovic, Sylvan Wallenstein, Yingwei Wu, Joseph I. Friedman |
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| Rok vydání: | 2011 |
| Předmět: |
Adult
Male medicine.medical_specialty Population Brain mapping Body Mass Index White matter Risk Factors Internal medicine Fractional anisotropy Image Processing Computer-Assisted medicine Humans education Biological Psychiatry Aged Psychiatric Status Rating Scales Brain Mapping education.field_of_study Brain Middle Aged medicine.disease Psychiatry and Mental health Diffusion Tensor Imaging medicine.anatomical_structure Schizophrenia Hypertension Cardiology Anisotropy Female Psychology Neuroscience Body mass index Diagnosis of schizophrenia Diffusion MRI |
| Zdroj: | Schizophrenia Research. 130:94-100 |
| ISSN: | 0920-9964 |
| DOI: | 10.1016/j.schres.2011.05.002 |
| Popis: | Recently, the negative effects of hypertension and elevated body mass index on cognitive functioning in schizophrenia have been reported (Friedman et al., 2010). Data suggests that cognitive changes in hypertensive patients from the general population may be mediated, in part, by white matter damage. Therefore, we performed diffusion tensor imaging (DTI) in the same subjects studied by Friedman et al. (2010) to investigate the effects of hypertension and elevated body mass index on the fractional anisotropy (FA) of several major white matter tracts. Significant interactions between a diagnosis of schizophrenia and hypertension on FA in several white matter regions were detected. Hypertension was associated with lower FA in the schizophrenic group and higher FA in the same tracts in the non-schizophrenic subjects. These results suggest hypertension-induced compensatory mechanisms in the brains of non-schizophrenic patients with hypertension which may be impaired in persons with schizophrenia. |
| Databáze: | OpenAIRE |
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