IL-4 promotor gene polymorphism in heart transplantation
| Autor: | M. G. J. Tilanus, J. van Kuik, Femke J Bijlsma, N. de Jonge, F. H. J. Gmelig Meyling, R.A. de Weger, A.H. Bruggink |
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| Rok vydání: | 2001 |
| Předmět: |
Pulmonary and Respiratory Medicine
Heart transplantation Transplantation medicine.medical_specialty biology business.industry Incidence (epidemiology) medicine.medical_treatment Cancer Promoter medicine.disease Gastroenterology Internal medicine parasitic diseases biology.protein Medicine Surgery Gene polymorphism Antibody Cardiology and Cardiovascular Medicine business Adverse effect Interleukin 4 |
| Zdroj: | The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation. 20(2) |
| ISSN: | 1557-3117 |
| Popis: | test. Results: Overall survival was borderline significantly different between all groups (OKT3: 52.4%, F-ATG: 44.3 %, THG: 67.5% and BT563: 51.8%; p 0.095). Causes of death were different between the four groups. OKT3 treated patients had the highest rate of death from graftsclerosis (40%) and BT 563 the highest rate in death from acute rejection (23%). In the THG group there was the lowest incidence of acute rejections (57.3%, 29.5 %, 18% and 50%; p 0.002). There was no difference in overall freedom from severe infections (90.5%, 81.8 %, 92.4% and 88.9%; p 0.232) and CMV-disease (80.9%, 79.6 %, 83.6% and 77.8%; p 0.822). The incidence of cancer was similar in all groups (14.3 %, 22.8 %, 11.7% and 11.1%; p 0.146), whereas there was a clear trend of lower incidence of graftsclerosis in THG treated patients (52.2 %, 38.0 %, 25.7% and 41.2%; p 0.053). Conclusions: Different Antibody induction protocols seem to be dissimilar in their immunmodulating function. Although all three studies were powered to detect differences in early rejection, long-term data show different incidence of development of graftsclerosis and on survival. Long-term adverse events were comparable and tolerable. These data clearly show that early immunmodulating influence of induction antibodies have longrange effects on the immune system. |
| Databáze: | OpenAIRE |
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