Apolipoprotein B correlates with intra-plaque necrotic core volume in stable coronary artery disease

Autor: Kazuaki Amami, Takayuki Ohwada, Yasuchika Takeishi, Kenichi Watanabe, Sayoko Yokokawa, Yuki Kanno, Takayuki Sakamoto, Kazuhiko Nakazato
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Male
Apolipoprotein B
Cardiovascular Procedures
medicine.medical_treatment
Coronary Artery Disease
030204 cardiovascular system & hematology
Pathology and Laboratory Medicine
Gastroenterology
Biochemistry
Coronary artery disease
chemistry.chemical_compound
0302 clinical medicine
Mathematical and Statistical Techniques
Intravascular ultrasound
Medicine and Health Sciences
030212 general & internal medicine
Prospective Studies
Coronary Arteries
education.field_of_study
Multidisciplinary
medicine.diagnostic_test
biology
Statistics
Arteries
Coronary Vessels
Lipids
medicine.anatomical_structure
Cholesterol
Physical Sciences
Regression Analysis
Medicine
Female
lipids (amino acids
peptides
and proteins)
Anatomy
Research Article
medicine.medical_specialty
Lipoproteins
Science
Population
Surgical and Invasive Medical Procedures
Research and Analysis Methods
03 medical and health sciences
Necrosis
Signs and Symptoms
Diagnostic Medicine
Internal medicine
medicine
Humans
Statistical Methods
education
Aged
Apolipoproteins B
Apolipoprotein A-I
business.industry
Cholesterol
HDL
Angioplasty
Percutaneous coronary intervention
Biology and Life Sciences
Proteins
Cholesterol
LDL
medicine.disease
Coronary arteries
Apolipoproteins
chemistry
Conventional PCI
biology.protein
Lesions
Cardiovascular Anatomy
Blood Vessels
business
Coronary Angioplasty
Biomarkers
Mathematics
Zdroj: PLoS ONE, Vol 14, Iss 2, p e0212539 (2019)
PLoS ONE
ISSN: 1932-6203
Popis: ObjectiveTo determine the relationship between plaque composition and low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), apolipoprotein B (Apo-B), and Apo-A1 using virtual-histology intravascular ultrasound (VH-IVUS).MethodsWe assessed plaque composition in patients with stable coronary artery disease (SCD) admitted to our hospital for percutaneous coronary intervention (PCI) between November 1, 2012, and March 10, 2015. Before PCI, fibrous (FI), fibrofatty (FF), necrotic core (NC), and dense calcium (DC) regions were evaluated using VH-IVUS, and the contributions of each to the culprit lesion volume were recorded. Plasma LDL-C, HDL-C, Apo-B, and Apo-A1 levels were assessed before PCI. The relationship between the regions on VH-IVUS and plasma lipid levels was assessed. Patients were categorized into low Apo-B (LAB) and high Apo-B (HAB) groups, based on the overall cohort median Apo-B level.ResultsWe enrolled 115 patients (median Apo-B, 91 mg/dL, male n = 88) with 57 and 58 patients in the LAB (Apo-B ≤ 90 mg/dL) and HAB (Apo-B ≥ 91 mg/dL) groups, respectively. Vessel, plaque, and %NC volumes were significantly greater in the HAB group than in the LAB group. The %FI, %FF, and %DC volumes were similar in both groups. In all 115 patients, the %NC volume correlated with LDL-C (r = 0.2353, P = 0.0114) and Apo-B (r = 0.2487, P = 0.0074) but not with HDL-C and Apo A-1. The high-sensitivity C-reactive protein level tended to be higher in the HAB group than in the LAB group. Multiple regression analysis showed that being male, Apo-A1, and Apo-B were significant predictors of %NC volume extent.ConclusionsElevated Apo-B level was related to the %NC in target coronary artery lesions in SCD patients, suggesting a role of Apo-B as a biomarker of unstable plaque in this population.
Databáze: OpenAIRE
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