Apolipoprotein B correlates with intra-plaque necrotic core volume in stable coronary artery disease
Autor: | Kazuaki Amami, Takayuki Ohwada, Yasuchika Takeishi, Kenichi Watanabe, Sayoko Yokokawa, Yuki Kanno, Takayuki Sakamoto, Kazuhiko Nakazato |
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Jazyk: | angličtina |
Rok vydání: | 2019 |
Předmět: |
Male
Apolipoprotein B Cardiovascular Procedures medicine.medical_treatment Coronary Artery Disease 030204 cardiovascular system & hematology Pathology and Laboratory Medicine Gastroenterology Biochemistry Coronary artery disease chemistry.chemical_compound 0302 clinical medicine Mathematical and Statistical Techniques Intravascular ultrasound Medicine and Health Sciences 030212 general & internal medicine Prospective Studies Coronary Arteries education.field_of_study Multidisciplinary medicine.diagnostic_test biology Statistics Arteries Coronary Vessels Lipids medicine.anatomical_structure Cholesterol Physical Sciences Regression Analysis Medicine Female lipids (amino acids peptides and proteins) Anatomy Research Article medicine.medical_specialty Lipoproteins Science Population Surgical and Invasive Medical Procedures Research and Analysis Methods 03 medical and health sciences Necrosis Signs and Symptoms Diagnostic Medicine Internal medicine medicine Humans Statistical Methods education Aged Apolipoproteins B Apolipoprotein A-I business.industry Cholesterol HDL Angioplasty Percutaneous coronary intervention Biology and Life Sciences Proteins Cholesterol LDL medicine.disease Coronary arteries Apolipoproteins chemistry Conventional PCI biology.protein Lesions Cardiovascular Anatomy Blood Vessels business Coronary Angioplasty Biomarkers Mathematics |
Zdroj: | PLoS ONE, Vol 14, Iss 2, p e0212539 (2019) PLoS ONE |
ISSN: | 1932-6203 |
Popis: | ObjectiveTo determine the relationship between plaque composition and low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), apolipoprotein B (Apo-B), and Apo-A1 using virtual-histology intravascular ultrasound (VH-IVUS).MethodsWe assessed plaque composition in patients with stable coronary artery disease (SCD) admitted to our hospital for percutaneous coronary intervention (PCI) between November 1, 2012, and March 10, 2015. Before PCI, fibrous (FI), fibrofatty (FF), necrotic core (NC), and dense calcium (DC) regions were evaluated using VH-IVUS, and the contributions of each to the culprit lesion volume were recorded. Plasma LDL-C, HDL-C, Apo-B, and Apo-A1 levels were assessed before PCI. The relationship between the regions on VH-IVUS and plasma lipid levels was assessed. Patients were categorized into low Apo-B (LAB) and high Apo-B (HAB) groups, based on the overall cohort median Apo-B level.ResultsWe enrolled 115 patients (median Apo-B, 91 mg/dL, male n = 88) with 57 and 58 patients in the LAB (Apo-B ≤ 90 mg/dL) and HAB (Apo-B ≥ 91 mg/dL) groups, respectively. Vessel, plaque, and %NC volumes were significantly greater in the HAB group than in the LAB group. The %FI, %FF, and %DC volumes were similar in both groups. In all 115 patients, the %NC volume correlated with LDL-C (r = 0.2353, P = 0.0114) and Apo-B (r = 0.2487, P = 0.0074) but not with HDL-C and Apo A-1. The high-sensitivity C-reactive protein level tended to be higher in the HAB group than in the LAB group. Multiple regression analysis showed that being male, Apo-A1, and Apo-B were significant predictors of %NC volume extent.ConclusionsElevated Apo-B level was related to the %NC in target coronary artery lesions in SCD patients, suggesting a role of Apo-B as a biomarker of unstable plaque in this population. |
Databáze: | OpenAIRE |
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