Vitamin D (FokI) Receptor Gene Polymorphism is associated with Vitamin D Deficiency and Chronic Musculoskeletal Pain. A meta-analysis
| Autor: | Ahmed Abdulahi Abdurahman, Khadijeh Mirzaei, Leila Khorrami-Nezhad |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Musculoskeletal pain
Nutrition and Dietetics biology business.industry Endocrinology Diabetes and Metabolism Chronic pain Medicine (miscellaneous) General Medicine Bioinformatics medicine.disease FokI vitamin D deficiency carbohydrates (lipids) 03 medical and health sciences 0302 clinical medicine Meta-analysis biology.protein medicine Vitamin D and neurology 030212 general & internal medicine Gene polymorphism Receptor business 030217 neurology & neurosurgery |
| Zdroj: | International Journal for Vitamin and Nutrition Research. 87:219-232 |
| ISSN: | 1664-2821 0300-9831 |
| DOI: | 10.1024/0300-9831/a000569 |
| Popis: | Abstract. Background: Musculoskeletal pain is the most common chronic pain experienced by older adults. The aim of this study is to explore the associations between vitamin D (FOKI) receptor gene polymorphism (VDR) and vitamin D deficiency (VDD) and chronic musculoskeletal pain. Methods: Cross-sectional studies published in English from January 2000 to January 2015which reported prevalence of chronic pain (CP) and chronic musculoskeletal pain (CMP) were included in this systematic review and meta-analysis. A heat map was used to visualize and observe the correlation between VDR and CMP, CP and VDD. Results: 20 studies (N = 216,365) were included in the analysis, which showed an overall pooled prevalence estimate of CMP and CP as 30.6 per 100 (95 % CI: 30.59, 30.69) and 27.9 per 100 (95 % CI: 27.68, 28.24) respectively. The heat map clustering analysis visualizes the similarity between CP and CMP. Moreover, a direct correlation was observed between the three disease conditions (namely CMP, CP, and VDD) and FokI VDR polymorphism (FF). Spearman’s correlation analyses with adjusted r2 revealed that there is a statistically significant interaction effect of the FF genotype and VDD on CMP (r2 = 0.19, p = 0.03), a marginally significant interaction effect of the ff genotype and VDD on CMP (r2 = 0.11, p = 0.08). VDD was also associated with increased CMP (r2 = 0.19, p = 0.028). The pooled estimates of the prevalence of CMP in this review were found to be high. Conclusion: FokI VDR gene polymorphism (FF) plays an important role in the relationship between VDD and CMP. |
| Databáze: | OpenAIRE |
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