Leucocytosis and thrombosis at diagnosis are associated with poor survival in polycythaemia vera: a population-based study of 327 patients
| Autor: | Morgane Mounier, Bjorn Andreasson, François Girodon, Khadija Abdulkarim, Peter Johansson, Marc Maynadié, Cédric Rossi, Gilles Bonicelli, Valérie Jooste |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Adult
Male Polycythaemia medicine.medical_specialty Leukocytosis Population Comorbidity Kaplan-Meier Estimate Leukocyte Count Young Adult Polycythemia vera Risk Factors Cause of Death Neoplasms hemic and lymphatic diseases White blood cell Internal medicine Epidemiology medicine Humans Risk factor education Polycythemia Vera Aged Proportional Hazards Models Aged 80 and over Heart Failure Sweden education.field_of_study Relative survival Proportional hazards model business.industry Thrombosis Hematology Middle Aged Prognosis medicine.disease Surgery Leukemia Myeloid Acute medicine.anatomical_structure Disease Progression Female France business Follow-Up Studies |
| Zdroj: | British Journal of Haematology. 160:251-254 |
| ISSN: | 0007-1048 |
| DOI: | 10.1111/bjh.12117 |
| Popis: | Three hundred and twenty-seven patients from two population-based cohorts with an established diagnosis of polycythaemia vera were studied for prognostic risk factors for survival and leukaemia in a long-term survey. The relative survival (RS) was 72% and 46% at 10 and 20 years respectively, from the time of diagnosis. Multivariate analysis identified age >70 years, white blood cell count >13 × 10(9) /l and thrombo-embolism at diagnosis as independent risk factors. Patients with two or three of these factors had a 10 year RS of 26%, compared with 59% and 84% in patients with one and no risk factors, respectively. Age and leucocyte count are the main predicting factors for survival in polycythaemia vera. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text