Outcome of testicular sperm retrieval procedures in non-obstructive azoospermia: percutaneous aspiration versus open biopsy
| Autor: | Cengiz Alatas, Ramazan Mercan, Basak Balaban, Senai Aksoy, Alp Nuhoglu, Bulent Urman, Aycan Isiklar |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Adult
Male endocrine system Pregnancy Rate medicine.medical_treatment Biopsy Biology Intracytoplasmic sperm injection Specimen Handling Andrology Pregnancy Testis medicine Humans Sperm Injections Intracytoplasmic reproductive and urinary physiology Azoospermia urogenital system Rehabilitation Biopsy Needle Obstetrics and Gynecology medicine.disease Embryo Transfer Spermatozoa Embryo transfer Testicular sperm extraction Pregnancy rate Reproductive Medicine Oligospermia Sperm Retrieval Female Embryo quality |
| Zdroj: | Human reproduction (Oxford, England). 15(7) |
| ISSN: | 0268-1161 |
| Popis: | The aim of this study was to evaluate whether the extraction of testicular spermatozoa with percutaneous versus open biopsy has an effect on the treatment outcome with intracytoplasmic sperm injection (ICSI) in men with non-obstructive azoospermia. Regardless of testicular size, follicle stimulating hormone concentration, and previous biopsy result, percutaneous testicular sperm aspiration (PTSA) using a 21-gauge butterfly needle was attempted first and if this failed testicular sperm extraction (TESE) was performed. In 63 men spermatozoa were found with PTSA whereas in 228 men TESE had to be undertaken. More men in the PTSA group had previously been diagnosed with hypospermatogenesis (82 versus 50%). Compared with the PTSA group, more men in the TESE group had germ cell aplasia (27 versus 10%) or maturation arrest (22 versus 8%). There was no difference between the groups regarding mean age of men and their partners, duration of stimulation, oestradiol concentration on the day of human chorionic gonadotrophin, number of oocytes retrieved, fertilization rate, and embryo quality between the two groups. The number of embryos transferred (4.38 versus 3.90) was significantly higher in the PTSA group (P < 0.05), reflecting the increased number of embryos available for transfer. Implantation rate per embryo was 20.7% in the PTSA and 13.3% in the TESE group (P < 0.05). Clinical pregnancy rates were 46 and 29% in the PTSA and TESE groups respectively (P < 0.05). Clinical abortion rates were similar (21.2 versus 24%). It is concluded that in men with non-obstructive azoospermia, easier sperm retrieval, which is most likely indicative of a more favourable histopathology, is associated with higher implantation rates per embryo. |
| Databáze: | OpenAIRE |
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