Protective effect of Uncaria tomentosa extract against oxidative stress and genotoxicity induced by glyphosate-Roundup® using zebrafish (Danio rerio) as a model
| Autor: | Osmar Tomazelli Júnior, Jacir Dal Magro, Leila Zanatta, Emily A Fantini, Cassiano L. Rambo, Aline Augusti Boligon, Glaucia Dal Santo, Elisa Sauer, Luan Marcos Valentini Lazzarotto, Kanandra T. Bertoncello, Anna Maria Siebel, Alan Grotto, Greicy M.M. Conterato, Denis B. Rosemberg, Solange Cristina Garcia, Bárbara da Costa |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Male Antioxidant Health Toxicology and Mutagenesis medicine.medical_treatment Glycine 010501 environmental sciences Pharmacology medicine.disease_cause Uncaria tomentosa Extract 01 natural sciences Antioxidants Lipid peroxidation 03 medical and health sciences chemistry.chemical_compound medicine Uncaria tomentosa Environmental Chemistry Animals Cat's Claw Zebrafish 0105 earth and related environmental sciences biology Chemistry Herbicides Plant Extracts General Medicine South America biology.organism_classification Pollution Acute toxicity Oxidative Stress 030104 developmental biology Liver Female Lipid Peroxidation Micronucleus Oxidative stress Genotoxicity DNA Damage |
| Zdroj: | Environmental science and pollution research international. 25(12) |
| ISSN: | 1614-7499 |
| Popis: | Oxidative stress and DNA damage are involved in the glyphosate-based herbicide toxicity. Uncaria tomentosa (UT; Rubiaceae) is a plant species from South America containing bioactive compounds with known beneficial properties. The objective of this work was to evaluate the antioxidant and antigenotoxic potential of UT extract in a model of acute exposure to glyphosate-Roundup® (GR) in zebrafish (Danio rerio). We showed that UT (1.0 mg/mL) prevented the decrease of brain total thiols, the increase of lipid peroxidation in both brain and liver, and the decrease of liver GPx activity caused after 96 h of GR (5.0 mg/L) exposure. In addition, UT partially protected against the increase of micronucleus frequency induced by GR exposure in fish brain. Overall, our results indicate that UT protects against damage induced by a glyphosate-based herbicide by providing antioxidant and antigenotoxic effects, which may be related to the phenolic compounds identified in the extract. |
| Databáze: | OpenAIRE |
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