Evidence for a storage pool defect in platelets from cirrhotic patients with defective aggregation
| Autor: | Giuseppe G. Nenci, Luisa Orlandi, Antonella Simoni, Paolo Romagnoli, Giacomo Laffi, Fabio Marra, Paolo Gresele, Paolo Gentilini, Olga Bartolini, Anna Palermo, Maria Laura Selli |
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| Rok vydání: | 1992 |
| Předmět: |
Adult
Blood Platelets Liver Cirrhosis Male Serotonin Pathology medicine.medical_specialty Storage pool Cirrhosis Platelet Aggregation Platelet aggregation Platelet Factor 4 Gastroenterology chemistry.chemical_compound Adenosine Triphosphate Internal medicine medicine Coagulopathy Humans Platelet Agrégation Mild disease Aged Hepatology business.industry Middle Aged beta-Thromboglobulin medicine.disease chemistry Female Blood Platelet Disorders business Adenosine triphosphate |
| Zdroj: | Gastroenterology. 103:641-646 |
| ISSN: | 0016-5085 |
| DOI: | 10.1016/0016-5085(92)90859-w |
| Popis: | The mechanisms underlying the defective platelet function in cirrhotic patients were investigated. Eleven cirrhotic patients with mild disease (group 1), 20 patients with severe cirrhosis (group 2), and 31 controls were studied. Platelet aggregation was significantly reduced in cirrhotics compared with controls. Compared with controls, cirrhotic patients in group 2 showed a significant reduction in the total content of adenosine triphosphate (57.8 +/- 7.8 vs. 26.1 +/- 6.3 mumol/10(11) platelets; P less than 0.05), 5-hydroxytryptamine (285 +/- 26 vs. 104 +/- 38 nmol/10(11) platelets; P less than 0.05), beta-thromboglobulin (2129 +/- 120 vs. 1223 +/- 161 ng/10(8) platelets; P less than 0.01), and platelet factor 4 (1389 +/- 108 vs. 805 +/- 176 ng/10(8) platelets; P less than 0.05). In patients with severe disease, an increase in plasma beta-thromboglobulin-platelet factor 4 ratio, an index of in vivo platelet activation, was observed (controls, 3.50 +/- 0.50; group 1, 4.02 +/- 0.80; and group 2, 6.59 +/- 1.15). Our data indicate the existence of a platelet storage pool defect, which may favor the bleeding tendency of cirrhotic patients. |
| Databáze: | OpenAIRE |
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