The effect of an encapsulated nutrient mixture on food intake and satiety : A double-blind randomized cross-over proof of concept study
| Autor: | Annick M. E. Alleleyn, Henk F. J. Hendriks, Adrian A. M. Masclee, Daniel Keszthelyi, Ellen Wilms, Sinéad B. Bleiel, Mark van Avesaat, Freddy J. Troost, Dina Ripken |
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| Přispěvatelé: | Interne Geneeskunde, RS: NUTRIM - R2 - Liver and digestive health, MUMC+: MA Med Staf Artsass Interne Geneeskunde (9), Promovendi NTM, RS: FSE UCV Program - 1 - Lijn 2: Voedingsinnovatie en gezondheid, MUMC+: MA Maag Darm Lever (9) |
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Blood Glucose Male Nationale Raad voor Landbouwkundig Onderzoek TNO Visual Analog Scale Hunger TRANSIT Eating 0302 clinical medicine APPETITE Casein Weight management Intestine Small Ingestion FABULESS OLIBRA Food science Meals media_common Human Nutrition & Health Meal Nutrition and Dietetics Cross-Over Studies Chemistry INFUSION digestive oral and skin physiology Humane Voeding & Gezondheid Area under the curve Middle Aged Postprandial Period HORMONE-RELEASE medicine.anatomical_structure FAT EMULSION Area Under Curve Female Digestion lcsh:Nutrition. Foods and food supply YOGURT Adult Carbohydrate Adolescent media_common.quotation_subject 030209 endocrinology & metabolism lcsh:TX341-641 Capsules Satiation Proof of Concept Study Article 03 medical and health sciences Young Adult Double-Blind Method medicine Humans Aged Distal release 030109 nutrition & dietetics ANTROPYLORODUODENAL MOTILITY Protein Appetite Nutrients Overweight Encapsulated nutrient mixture Small intestine Satiety ENERGY-INTAKE ILEAL BRAKE Food Science |
| Zdroj: | Nutrients, 10(11) Nutrients Nutrients 10 (2018) 11 Volume 10 Issue 11 Nutrients, Vol 10, Iss 11, p 1787 (2018) Nutrients, 10(11):1787. Multidisciplinary Digital Publishing Institute (MDPI) |
| ISSN: | 2072-6643 |
| Popis: | Activation of the intestinal brake by infusing nutrients into the distal small intestine with catheters inhibits food intake and enhances satiety. Encapsulation of macronutrients, which protects against digestion in the proximal gastrointestinal tract, can be a non-invasive alternative to activate this brake. In this study, we investigate the effect of oral ingestion of an encapsulated casein and sucrose mixture (active) targeting the distal small intestine versus a control product designed to be released in the stomach on food intake, satiety, and plasma glucose concentrations. Fifty-nine volunteers received the active and control product on two separate test days. Food intake was determined during an ad libitum meal 90 min after ingestion of the test product. Visual analogue scale scores for satiety and blood samples for glucose analysis were collected at regular intervals. Ingestion of the active product decreased food intake compared to the control product (655 kcal compared with 699 kcal, respectively, p < 0.05). The area under the curve (AUC) for hunger was decreased (p < 0.05) and AUC for satiety was increased (p < 0.01) after ingestion of the active product compared to the control product. Ingestion of an encapsulated protein-carbohydrate mixture resulted in inhibition of food intake compared to a non-encapsulated control product. |
| Databáze: | OpenAIRE |
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